Mal-PEG2-alcohol

Base Information

• Chemical Name: Mal-PEG2-alcohol
• CAS No.: 34321-81-8
• Molecular Formula: C8H11NO4
• Molecular Weight: 185.18
• Mol file: 34321-81-8.mol

Synonyms:

Chemical Property of Mal-PEG2-alcohol

Chemical Property:

• Boiling Point: 361.7±22.0 °C(Predicted)
• PKA: 14.35±0.10(Predicted)
• PSA: 66.84000
• Density: 1.317±0.06 g/cm3(Predicted)
• LogP: -1.14180

Purity/Quality:

98%,99%, ^*data from raw suppliers

Mal-PEG2-alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Mal-PEG2-alcohol is a PEG linker containing a maleimide group and a hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Technology Process of Mal-PEG2-alcohol

There total 4 articles about Mal-PEG2-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-methoxycarbonylmaleimide (55750-48-6) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrrole-2,5-dione (34321-81-8)

Guidance literature:

With sodium hydrogencarbonate; at 0 - 23 ℃; for 1h;

DOI:10.1021/ja054482w

Reference yield: 41.0%

N-[2-(2-hydroxyethoxy)ethyl]-exo-3,6-epoxy-1,2,3,6-tetrahydrophthalimide (916852-34-1) → 1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrrole-2,5-dione (34321-81-8)

Guidance literature:

In toluene; for 7h; Reflux;

Reference yield:

N-ethoxycarbonylmaleinimide (55750-49-7) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrrole-2,5-dione (34321-81-8)

Guidance literature:

With sodium hydrogencarbonate; In water;

DOI:10.1021/jm2000272

upstream raw materials:

N-methoxycarbonylmaleimide

2-(2-Aminoethoxy)ethanol

N-ethoxycarbonylmaleinimide

N-[2-(2-hydroxyethoxy)ethyl]-exo-3,6-epoxy-1,2,3,6-tetrahydrophthalimide

Downstream raw materials:

2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)acetaldehyde

4-<2-Diaethylphosphono-vinyl>-cyclohexen-1-phosphonsaeure-(3)-diaethylester

Refernces

• 1、 Raouane, Mouna,Desmaele, Didier,Gilbert-Sirieix, Marie,Gueutin, Claire,Zouhiri, Fatima,Bourgaux, Claudie,Lepeltier, Elise,Gref, Ruxandra,Ben Salah, Ridha,Clayman, Gary,Massaad-Massade, Liliane,Couvreur, Patrick. "Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma". . p. 4067 - 4076. Retrieved 2011.
• 2、 -. "Linker, linker-containing antibody conjugate drug and application of linker". Paragraph 0171-0173; 0183; 0187-0188. . Retrieved 2020/02/20.
• 3、 Elgersma, Ronald C.,Coumans, Ruud G. E.,Huijbregts, Tijl,Menge, Wiro M. P. B.,Joosten, John A. F.,Spijker, Henri J.,De Groot, Franciscus M. H.,Van Der Lee, Miranda M. C.,Ubink, Ruud,Van Den Dobbelsteen, Diels J.,Egging, David F.,Dokter, Wim H. A.,Verheijden, Gijs F. M.,Lemmens, Jacques M.,Timmers, C. Marco,Beusker, Patrick H.. "Design, synthesis, and evaluation of linker-duocarmycin payloads: Toward selection of HER2-targeting antibody-drug conjugate SYD985". . p. 1813 - 1835. Retrieved 2015/06/16.