5'-FLUORO-2'-HYDROXY-2-PHENYLACETOPHENONE

Base Information

• Chemical Name: 5'-FLUORO-2'-HYDROXY-2-PHENYLACETOPHENONE
• CAS No.: 343-59-9
• Molecular Formula: C14H11FO2
• Molecular Weight: 230.239
• Hs Code.: 2914790090
• Mol file: 343-59-9.mol

Synonyms:1-(5-Fluoro-2-hydroxy-phenyl)-2-phenyl-ethanone;5-Fluor-2-hydroxy-desoxybenzoin;5-Fluor-2-hydroxyphenyl-benzylketon (4-Fluor-2-phenylacetyl-phenol);5-fluoro-2-hydroxy-deoxybenzoin;1-(5-Fluoro-2-hydroxyphenyl)-2-phenylethanone;5-Fluor-2-hydroxyphenyl-benzyl-keton;

Chemical Property of 5'-FLUORO-2'-HYDROXY-2-PHENYLACETOPHENONE

Chemical Property:

• Melting Point: 84.5 °C (light petroleum)
• PSA: 37.30000
• LogP: 2.95670

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Fluoro-2-hydroxyphenyl)-2-phenylethanone 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 5'-FLUORO-2'-HYDROXY-2-PHENYLACETOPHENONE

There total 8 articles about 5'-FLUORO-2'-HYDROXY-2-PHENYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzeneacetic acid 4-fluorophenyl ester (62433-23-2) → 1-(5-fluoro-2-hydroxyphenyl)-2-phenylethanone (343-59-9)

Guidance literature:

With aluminium trichloride; at 150 - 180 ℃;

Reference yield: 56.0%

phenylacetic acid (103-82-2) + 1-fluoro-4-methoxybenzene (459-60-9) → 1-(5-fluoro-2-hydroxyphenyl)-2-phenylethanone (343-59-9)

Guidance literature:

phenylacetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 0.5h;

1-fluoro-4-methoxybenzene; aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

4-Fluorophenol (371-41-5) → 1-(5-fluoro-2-hydroxyphenyl)-2-phenylethanone (343-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Et₃N / diethyl ether / 1 h / Heating

2: 85 percent / AlCl₃ / 150 - 180 °C

With aluminium trichloride; triethylamine; In diethyl ether;

upstream raw materials:

5-fluoro-2-methoxy-deoxybenzoin

pyridine hydrochloride

benzeneacetic acid 4-fluorophenyl ester

4-Fluorophenol

Downstream raw materials:

6-fluoro-2-methyl-3-phenyl-4H-chromen-4-one

6-Fluoro-3-phenyl-2-propyl-4H-chromen-4-one

C₂₁H₂₀FNO₄

2-Ethyl-6-fluoro-3-phenyl-4H-chromen-4-one

Refernces

• 1、 Krause,Rouleau,Stark,Garbarg,Schwartz,Schunack. "Structure-activity relationships of novel azomethine prodrugs of the histamine H3-receptor agonist (R)-α-methylhistamine: From alkylaryl to substituted diaryl derivatives". . p. 720 - 726. Retrieved 2007/10/03.