3-[(carboxymethyl)sulfanyl]-4,4,5,5,6,6,6-heptafluorohexanoic acid

Base Information

• Chemical Name: 3-[(carboxymethyl)sulfanyl]-4,4,5,5,6,6,6-heptafluorohexanoic acid
• CAS No.: 424-55-5
• Molecular Formula: C₈H₇F₇O₄S
• Molecular Weight: 332.196
• Mol file: 424-55-5.mol

Synonyms:NSC146413

Chemical Property of 3-[(carboxymethyl)sulfanyl]-4,4,5,5,6,6,6-heptafluorohexanoic acid

Chemical Property:

• Vapor Pressure: 1.64E-05mmHg at 25°C
• Boiling Point: 339.9°Cat760mmHg
• Flash Point: 159.4°C
• Density: 1.64g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(carboxymethyl)sulfanyl]-4,4,5,5,6,6,6-heptafluorohexanoic acid

There total 4 articles about 3-[(carboxymethyl)sulfanyl]-4,4,5,5,6,6,6-heptafluorohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethoxycarbonylmethylsulfanyl-4,4,5,5,6,6,6-heptafluoro-hexanoic acid ethyl ester (1580-17-2) → 3-Heptafluorpropyl-4-thia-hexandisaeure (424-55-5)

Guidance literature:

With formic acid; beim Abdestillieren des entstehenden Aethylformiats;

DOI:10.1021/ja01540a053

Reference yield:

2H,3H-heptafluoro-hex-2t-enoic acid ethyl ester (37759-79-8) → 3-Heptafluorpropyl-4-thia-hexandisaeure (424-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; piperidine; aqueous benzyl-trimethyl-ammonium hydroxide

2: aqueous formic acid / beim Abdestillieren des entstehenden Aethylformiats

With piperidine; formic acid; diethyl ether; N-benzyl-trimethylammonium hydroxide;

DOI:10.1021/ja01540a053

Reference yield:

4,4,5,5,6,6,6-heptafluoro-3-mercapto-hexanoic acid ethyl ester (377-64-0) → 3-Heptafluorpropyl-4-thia-hexandisaeure (424-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; sodium hydride / beim anschliessenden Erwaermen mit Bromessigsaeure-aethylester

2: aqueous formic acid / beim Abdestillieren des entstehenden Aethylformiats

With formic acid; diethyl ether; sodium hydride;

DOI:10.1021/ja01540a053

upstream raw materials:

3-ethoxycarbonylmethylsulfanyl-4,4,5,5,6,6,6-heptafluoro-hexanoic acid ethyl ester

2H,3H-heptafluoro-hex-2t-enoic acid ethyl ester

4,4,5,5,6,6,6-heptafluoro-3-mercapto-hexanoic acid ethyl ester