2-(4-Fluorophenyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine
• CAS No.: 347-12-6
• Molecular Formula: C13H9FN2
• Molecular Weight: 212.226
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80352756
• Nikkaji Number: J1.118.401D
• Wikidata: Q82130073
• ChEMBL ID: CHEMBL1524763
• Mol file: 347-12-6.mol

Synonyms:2-(4-fluorophenyl)imidazo[1,2-a]pyridine;347-12-6;2-(4-Fluoro-phenyl)-imidazo[1,2-a]pyridine;2-(4-Fluorophenyl)H-imidazo[1,2-a]pyridine;CBMicro_014174;Cambridge id 5218460;Oprea1_259396;Oprea1_524985;MLS001212604;SCHEMBL2595462;CHEMBL1524763;DTXSID80352756;PNOFVTHZVLYOFR-UHFFFAOYSA-N;HMS1680I08;HMS2822B10;SMSF0004679;BBL022272;CCG-15402;MFCD00269178;STK743765;AKOS000678202;CB09916;AS-38315;SMR000515779;BIM-0014180.P001;CS-0206414;AB00075625-01;EN300-1228513;A874888;SR-01000396407;SR-01000396407-1;F0037-8617

Chemical Property of 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 165-166 °C
• PKA: 6.54±0.50(Predicted)
• PSA: 17.30000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 3.14040
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 212.07497646
• Heavy Atom Count: 16
• Complexity: 238

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

• Canonical SMILES: C1=CC2=NC(=CN2C=C1)C3=CC=C(C=C3)F
• Uses: 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine

Technology Process of 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine

There total 36 articles about 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-aminopyridine (504-29-0) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-fluorophenyl)imidazo[1,2-a]pyridine (347-12-6)

Guidance literature:

In neat (no solvent); at 25 - 30 ℃; Milling; Green chemistry;

DOI:10.1002/jhet.4164

Reference yield: 91.0%

2-aminopyridine (504-29-0) + 1-ethyl-4-fluorobenzene (459-47-2) → 2-(4-fluorophenyl)imidazo[1,2-a]pyridine (347-12-6)

Guidance literature:

1-ethyl-4-fluorobenzene; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In water; at 60 ℃; for 4h;

2-aminopyridine; With sodium hydrogencarbonate; In water; at 80 ℃; for 2h;

Reference yield: 91.0%

2-aminopyridine (504-29-0) + 1-(4-fluorophenyl)-2-diazoethan-1-one (3488-44-6) → 2-(4-fluorophenyl)imidazo[1,2-a]pyridine (347-12-6)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 80 ℃; for 2.5h;

DOI:10.1016/j.tetlet.2007.08.090

upstream raw materials:

2-aminopyridine

2-bromo-4'-fluoroacetophenone

2-(4-fluorophenyl)-3-chloroimidazo<1,2-a>pyridine

1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone

Downstream raw materials:

3-iodo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine

C₁₈H₁₂FN₃

C₁₉H₁₂FN₃O₂

2-(4-fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde

Refernces

• 1、 Godugu, Kumar,Nallagondu, Chinna Gangi Reddy. "Solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry". . p. 250 - 259. Retrieved 2020/10/23.
• 2、 Khonde, Nilesh S.,Said, Madhukar S.,Sabane, Jagjivan K.,Gajbhiye, Jayant M.,Kumar, Pradeep. "Metal-free, Tf2NH-catalyzed 1, 6-conjugate addition of imidazopyridine to para-quinone methides: Easy access to C3-functionalized triarylmethane imidazopyridine". supporting information. . Retrieved 2021/10/30.