2,4-Dihydroxy-3-formyl-6-methylbenzoic acid methyl ester

Base Information

• Chemical Name: 2,4-Dihydroxy-3-formyl-6-methylbenzoic acid methyl ester
• CAS No.: 34874-90-3
• Molecular Formula: C10H10O5
• Molecular Weight: 210.186
• Mol file: 34874-90-3.mol

Synonyms:methyl hematommate;Methyl haematomate;methyl 2,4-dihydroxy-3-formyl-6-methylbenzoate;formyl-3-dihydroxy-2,4-methyl-6-benzoate de methyle;Methyl haematommate;Benzoic acid,3-formyl-2,4-dihydroxy-6-methyl-,methyl ester;3-formyl-2,4-dihydroxy-6-methylbenzoic acid methyl ester;

Chemical Property of 2,4-Dihydroxy-3-formyl-6-methylbenzoic acid methyl ester

Chemical Property:

• Melting Point: 146 °C
• Boiling Point: 298.8±40.0 °C(Predicted)
• PKA: 6.49±0.28(Predicted)
• PSA: 83.83000
• Density: 1.381±0.06 g/cm3(Predicted)
• LogP: 1.00530

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dihydroxy-3-formyl-6-methylbenzoic acid methyl ester

There total 14 articles about 2,4-Dihydroxy-3-formyl-6-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Dichloromethyl methyl ether (4885-02-3) + methyl orsellinate (3187-58-4) → methyl haematommate (34874-90-3)

Guidance literature:

methyl orsellinate; With titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

Dichloromethyl methyl ether; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b04486

Reference yield: 86.0%

methyl 3-formyl-2,4-dimethoxy-6-methylbenzoate (126717-83-7) → methyl haematommate (34874-90-3)

Guidance literature:

With boron trichloride; In dichloromethane; for 3.5h; Ambient temperature;

DOI:10.1002/hlca.19890720524

Reference yield: 80.0%

methyl orsellinate (3187-58-4) + dicyanozinc (557-21-1) → methyl haematommate (34874-90-3)

Guidance literature:

With aluminium trichloride; In diethyl ether;

DOI:10.1016/S0040-4039(99)01015-1

upstream raw materials:

hydrogen cyanide

methyl orsellinate

atranorin

4-(3-formyl-2,4-dihydroxy-6-methyl-benzoyloxy)-2-hydroxy-6-methyl-benzoic acid

Downstream raw materials:

atranol

2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester

methyl 3-hydroxy orsellinate

3-formyl-2,4,5-trihydroxy-6-methyl-benzoic acid methyl ester

Refernces

• 1、 Dong, Chunmao,Huo, Luqiong,Liu, Hongxin,Lu, Xiuxiang,Qiu, Shengxiang,Tan, Haibo,Wang, Miaomiao,Yang, Bao,Yuan, Yunfei,Zhang, Wenge. "Biomimetic Total Syntheses of Sanctis A-B with Structure Revision". supporting information. . Retrieved 2020/02/15.
• 2、 Proksa,Adamcova,Sturdikova,Fuska. "Metabolites of Pseudevernia furfuracea (L.) Zopf. and their inhibition potential of proteolytic enzymes". . p. 282 - 283. Retrieved 2007/10/02.