1H-INDAZOLE-3-(N-METHOXY-METHYL)CARBAMIDE

Base Information

• Chemical Name: 1H-INDAZOLE-3-(N-METHOXY-METHYL)CARBAMIDE
• CAS No.: 351457-12-0
• Molecular Formula: C10H11N3O2
• Molecular Weight: 205.216
• Hs Code.: 2933990090
• Mol file: 351457-12-0.mol

Synonyms:1H-Indazole-3-carboxamide,N-methoxy-N-methyl;1H-indazole-3-carboxylic acid methoxy-methyl-amide;

Chemical Property of 1H-INDAZOLE-3-(N-METHOXY-METHYL)CARBAMIDE

Chemical Property:

• PSA: 58.22000
• LogP: 1.19630

Purity/Quality:

99% ^*data from raw suppliers

N-Methoxy-N-methyl-1H-indazole-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDAZOLE-3-(N-METHOXY-METHYL)CARBAMIDE

There total 9 articles about 1H-INDAZOLE-3-(N-METHOXY-METHYL)CARBAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 1H-Indazole-3-carboxylic acid (4498-67-3) → 1H-indazole-3-carboxylic acid methoxy(methyl)amide (351457-12-0)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; 1H-Indazole-3-carboxylic acid; With pyridine; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.ejmech.2021.113215

Reference yield: 79.0%

CH2Cl2-ether + 1H-Indazole-3-carboxylic acid (4498-67-3) → 1H-indazole-3-carboxylic acid methoxy(methyl)amide (351457-12-0)

Guidance literature:

With hydrogenchloride; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 56.0%

1H-Indazole-3-carboxylic acid (4498-67-3) + N,0-dimethylhydroxylamine (1117-97-1) → 1H-indazole-3-carboxylic acid methoxy(methyl)amide (351457-12-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 23 ℃; for 18h;

upstream raw materials:

tert-butyl 3-{[methoxy(methyl)amino]carbonyl}-1H-indazole-1-carboxylate

3,5-difluoroanisol

N,O-dimethylhydroxylamine*hydrochloride

1H-Indazole-3-carboxylic acid

Downstream raw materials:

(1H-indazol-3-yl)(phenyl)methanone

(3-{[tert-butyl(diphenyl)silyl]oxy}phenyl)(1H-indazol-3-yl)methanone

3-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-indazole-1-carboxylic acid tert-butyl ester

tert-butyl 3-formyl-1H-indazole-1-carboxylate

Refernces

• 1、 -. "Indazole compounds and preparation method and application thereof". Paragraph 0019-0020. . Retrieved 2019/09/14.
• 2、 -. "THERAPEUTIC INHIBITORY COMPOUNDS". Paragraph 00236. . Retrieved 2018/02/22.