2,4,5-trichlorobenzaldehyde

Base Information

• Chemical Name: 2,4,5-trichlorobenzaldehyde
• CAS No.: 35696-87-8
• Molecular Formula: C7H3Cl3O
• Molecular Weight: 209.459
• Hs Code.: 2913000090
• Mol file: 35696-87-8.mol

Synonyms:2,5-Trichloroanisole;2,4,5-Trichlor-benzaldehyd;2.4.5-Trichlor-1-methoxy-benzol;<2,4,5-trichlor-phenyl>-methyl-aether;Anisole,2,4,5-trichloro;Benzene,1,2,4-trichloro-5-methoxy;2,4,5-Trichlor-anisol;Benzaldehyde, 2,4,5-trichloro-;Anisole,4,5-trichloro;2,4,5-trichloro-anisole;1,2,4-trichloro-5-methoxy-benzene;2,4,5-trichloro-benzaldehyde;

Chemical Property of 2,4,5-trichlorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00545mmHg at 25°C
• Melting Point: 111-113 °C
• Boiling Point: 274.3oC at 760 mmHg
• Flash Point: 113.9oC
• PSA: 17.07000
• Density: 1.529g/cm3
• LogP: 3.45930

Purity/Quality:

99% ^*data from raw suppliers

2,4,5-Trichlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,5-trichlorobenzaldehyde

There total 10 articles about 2,4,5-trichlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,4,5-trichloroiodobenzene (7145-82-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4,5-trichlorobenzaldehyde (35696-87-8)

Guidance literature:

2,4,5-trichloroiodobenzene; With isopropylmagnesium halide; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 23 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01292

Reference yield: 92.0%

3,4-dichlorobenzaldehyde (6287-38-3) → 2,4,5-trichlorobenzaldehyde (35696-87-8)

Guidance literature:

With N-chloro-succinimide; palladium diacetate; silver trifluoroacetate; anthranilic acid; trifluoroacetic acid; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Sealed tube;

DOI:10.1021/jacs.6b11188

Reference yield: 79.0%

3-(2,4,5-trichloro-phenyl)-acrylic acid tert-butyl ester (208512-51-0) → 2,4,5-trichlorobenzaldehyde (35696-87-8)

Guidance literature:

3-(2,4,5-trichloro-phenyl)-acrylic acid tert-butyl ester; With ozone; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/S0968-0896(02)00335-8

upstream raw materials:

5-nitro-2,4-dichlorobenzaldehyde

1,2,4-trichloro-5-chloromethyl-benzene

sulfuric acid

1,2,4-trichloro-5-dichloromethyl-benzene

Downstream raw materials:

2,4,5-trichloro-cinnamic acid

1-(2,4,5-trichloro-phenyl)-ethanol

1-[5-Acetyl-4-(2,4,5-trichlorophenyl)-1,2,6-trimethyl-1,4-dihydropyridin-3-yl]ethanone

Refernces

• 1、 Chen, Xiao-Yang,Sorensen, Erik J.. "Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups". supporting information. p. 2789 - 2792. Retrieved 2018/03/08.
• 2、 Chen, Xiao-Yang,Ozturk, Seyma,Sorensen, Erik J.. "Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group". supporting information. p. 6280 - 6283. Retrieved 2017/12/08.