4,4-dimethoxybutanoic acid

Base Information

• Chemical Name: 4,4-dimethoxybutanoic acid
• CAS No.: 35848-90-9
• Molecular Formula: C6H12O4
• Molecular Weight: 148.159
• Mol file: 35848-90-9.mol

Synonyms:

Chemical Property of 4,4-dimethoxybutanoic acid

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

4,4-DIMETHOXYBUTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-dimethoxybutanoic acid

There total 3 articles about 4,4-dimethoxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4,4-dimethoxybutanoate (4220-66-0) → 4,4-dimethoxybutan-1-oic acid (35848-90-9)

Guidance literature:

With sodium hydroxide; In methanol; at 0 ℃;

DOI:10.1016/S0040-4020(01)80074-0

Reference yield:

4-oxobutanoic acid methyl ester (13865-19-5) + trimethyl orthoformate (149-73-5) → 4,4-dimethoxybutan-1-oic acid (35848-90-9)

Guidance literature:

With hydrogen cation; In methanol;

Reference yield:

methyl 4-nitrobutyrate (13013-02-0) + sodium methylate (124-41-4) → 4,4-dimethoxybutan-1-oic acid (35848-90-9)

Guidance literature:

methyl 4-nitrobutyrate; sodium methylate; With sulfuric acid; In methanol;

With sodium hydroxide; In methanol;

DOI:10.1021/acs.joc.5b01301

upstream raw materials:

methyl 4,4-dimethoxybutanoate

4-oxobutanoic acid methyl ester

trimethyl orthoformate

methyl 4-nitrobutyrate

Downstream raw materials:

4,4-Dimethoxy-butyric acid (2R,3S,4aR,6S,8S,8aR)-2-allyl-6-(3-benzyloxy-propyl)-2,8a-dimethyl-8-trimethylsilanyloxy-octahydro-pyrano[3,2-b]pyran-3-yl ester

C₃₂H₄₄O₇

(4S,5R)-4-allyl-5-methyl-2-phenyl-1,3-dioxan-5-yl 4,4-dimethoxybutanoate

(2R,3R,4S,5S,6S)-2,6-diallyl-4-(benzyloxy)-5-(4,4-dimethoxybutanoyloxy)-tetrahydro-2H-pyran-3-yl 5,5-dimethoxypentanoate

Refernces

• 1、 Yin, Zhiping,Liu, Zengjin,Huang, Zhenggang,Chu, Yang,Chu, Zhiwen,Hu, Jia,Gao, Lu,Song, Zhenlei. "Synthesis of functionalized γ-lactone via Sakurai exo -cyclization/rearrangement of 3,3-bis(silyl) enol ester with a tethered acetal". supporting information. p. 1553 - 1556. Retrieved 2015/03/30.
• 2、 -. "AMIDE DERIVATIVE". Page/Page column 72. . Retrieved 2012/02/05.