Ether, benzyl 2-bromo-1-(bromomethyl)ethyl

Base Information

• Chemical Name: Ether, benzyl 2-bromo-1-(bromomethyl)ethyl
• CAS No.: 35995-55-2
• Molecular Formula: C10H12Br2O
• Molecular Weight: 308.013
• Mol file: 35995-55-2.mol

Synonyms:([2-Bromo-1-(bromomethyl)ethoxy]methyl)benzene;2-bromo-1-(bromomethyl)-1-(phenylmethoxy)ethane;Benzene,[[2-bromo-1-(bromomethyl)ethoxy]methyl];(((1,3-dibromopropan-2-yl)oxy)methyl)benzene;2-benzyloxy-1,3-dibromopropane;1,3-dibromo-2-O-benzyl glycerol;

Chemical Property of Ether, benzyl 2-bromo-1-(bromomethyl)ethyl

Chemical Property:

• Boiling Point: 148-155 °C(Press: 3 Torr)
• PSA: 9.23000
• Density: 1.635±0.06 g/cm3(Predicted)
• LogP: 3.36160

Purity/Quality:

99.3% ^*data from raw suppliers

{[2-Bromo-1-(bromomethyl)ethoxy]methyl}benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ether, benzyl 2-bromo-1-(bromomethyl)ethyl

There total 6 articles about Ether, benzyl 2-bromo-1-(bromomethyl)ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-O-benzylglycerol (14690-00-7) → (2-bromo-1-bromomethylethoxymethyl)benzene (35995-55-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.02.044

Reference yield: 70.0%

benzyl bromide (100-39-0) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → (2-bromo-1-bromomethylethoxymethyl)benzene (35995-55-2)

Guidance literature:

mercury(I) chloride; at 150 ℃; Heating / reflux;

Reference yield:

benzyl bromide (100-39-0) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → benzyl allyl ether (14593-43-2) + (2-bromo-1-bromomethylethoxymethyl)benzene (35995-55-2)

Guidance literature:

benzyl bromide; 1,2-Epoxy-3-bromopropane; With copper dichloride; at 155 - 160 ℃; for 11h; Large scale;

With sodium methylate; In methanol; at 20 ℃; Inert atmosphere; Large scale;

upstream raw materials:

benzyl bromide

1,2-Epoxy-3-bromopropane

2-O-benzylglycerol

carbon tetrabromide

Downstream raw materials:

diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate

1-methylsulfinyl-1-methylthio-3-benzyloxycyclobutane

7-(1-Benzhydryloxycarbonyl-3-benzyloxy-cyclobutyl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

diisoamyl 3-benzyloxycyclobutane-1,1-dicarboxylate

Refernces

• 1、 -. "CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATING AGENTS". Paragraph 00179. . Retrieved 2020/10/20.
• 2、 -. "Hydroxypurine compound and use thereof". Paragraph 0142; 0143; 0144; 0145. . Retrieved 2016/10/08.