2,3-DIHYDRO-1-BENZOFURAN-7-YLMETHYLAMINE

Base Information

• Chemical Name: 2,3-DIHYDRO-1-BENZOFURAN-7-YLMETHYLAMINE
• CAS No.: 361393-65-9
• Molecular Formula: C9H11NO
• Molecular Weight: 149.19000
• Mol file: 361393-65-9.mol

Synonyms:2,3-dihydro-1-benzofuran-7-ylmethylamine;

Chemical Property of 2,3-DIHYDRO-1-BENZOFURAN-7-YLMETHYLAMINE

Chemical Property:

• PSA: 35.25000
• LogP: 1.78050

Purity/Quality:

99% ^*data from raw suppliers

2,3-dihydro-1-benzofuran-7-ylmethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-DIHYDRO-1-BENZOFURAN-7-YLMETHYLAMINE

There total 10 articles about 2,3-DIHYDRO-1-BENZOFURAN-7-YLMETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(azidomethyl)-2,3-dihydro-1-benzofuran (870061-73-7) → 1-(2,3-dihydro-1-benzofuran-7-yl)methanamine (361393-65-9)

Guidance literature:

7-(azidomethyl)-2,3-dihydro-1-benzofuran; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.5h;

With sodium hydroxide; water;

With hydrogenchloride; potassium carbonate; more than 3 stages;

Reference yield:

2,3-dihydrobenzofuran-7-carboxamide (134401-97-1) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → 1-(2,3-dihydro-1-benzofuran-7-yl)methanamine (361393-65-9)

Guidance literature:

With ammonium hydroxide; sodium hydroxide; sodium borohydrid; iodine; In tetrahydrofuran; methanol; tert-butyl methyl ether;

Reference yield:

2,3-dihydro-1-benzofuran-7-ylmethanol (151155-53-2) → 1-(2,3-dihydro-1-benzofuran-7-yl)methanamine (361393-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 22 °C

2: sodium azide / N,N-dimethyl-formamide / 22 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; sodium azide; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.04.024

upstream raw materials:

7-(azidomethyl)-2,3-dihydro-1-benzofuran

2,3-dihydrobenzofuran-7-carboxamide

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2,3-dihydro-1-benzofuran-7-ylmethanol

Refernces

• 1、 -. "THERAPEUTIC FLUOROETHYLCYANO GUANIDINES". Page/Page column 10-11. . Retrieved 2008/12/04.
• 2、 -. "P2X7 receptor antagonists and methods of use". Page/Page column 22. . Retrieved 2010/11/27.