5-BROMO-2-PIPERIDIN-1-YLMETHYL-PYRIDINE

Base Information

• Chemical Name: 5-BROMO-2-PIPERIDIN-1-YLMETHYL-PYRIDINE
• CAS No.: 364794-78-5
• Molecular Formula: C₁₁H₁₅BrN₂
• Molecular Weight: 255.157
• Hs Code.: 2933990090
• Mol file: 364794-78-5.mol

Synonyms:5-Bromo-2-piperidin-1-ylmethyl-pyridine;

Chemical Property of 5-BROMO-2-PIPERIDIN-1-YLMETHYL-PYRIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 300.062oC at 760 mmHg
• Flash Point: 135.273oC
• PSA: 16.13000
• Density: 1.378g/cm3
• LogP: 2.76790

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-(piperidin-1-ylmethyl)pyridine 95.00 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-PIPERIDIN-1-YLMETHYL-PYRIDINE

There total 8 articles about 5-BROMO-2-PIPERIDIN-1-YLMETHYL-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperidine (110-89-4) + 5-bromo-2-(bromomethyl)pyridine (145218-19-5) → 5-bromo-2-(1-piperidinylmethyl)pyridine (364794-78-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/acs.jmedchem.5b00464

Reference yield: 82.0%

1-methylene-piperidinium; trifluoro-acetate + 2-iodo-5-bromopyridine (223463-13-6) → 5-bromo-2-(1-piperidinylmethyl)pyridine (364794-78-5)

Guidance literature:

2-iodo-5-bromopyridine; With isopropylmagnesium chloride; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.75h;

1-methylene-piperidinium; trifluoro-acetate; In tetrahydrofuran; dichloromethane; at 0 ℃;

DOI:10.1021/ol0400589

Reference yield:

5-bromo-2-(1-piperidinylcarbonyl)pyridine (934000-33-6) → 5-bromo-2-(1-piperidinylmethyl)pyridine (364794-78-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-iodo-5-bromopyridine

piperidine

5-bromo-pyridine-2-carbaldehyde

di(N-piperidinyl)methane

Refernces

• 1、 -. "Tetrahydroquinoline Derivatives And Their Pharmaceutical Use". . . Retrieved 2012/08/28.
• 2、 -. "COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS". Page/Page column 150. . Retrieved 2010/06/11.