2-(3,4-Dimethoxystyryl)quinoline

Base Information

• Chemical Name: 2-(3,4-Dimethoxystyryl)quinoline
• CAS No.: 75903-25-2
• Molecular Formula: C19H17NO2
• Molecular Weight: 291.349
• NSC Number: 59067
• Nikkaji Number: J2.006.646F
• ChEMBL ID: CHEMBL121001
• Mol file: 75903-25-2.mol

Synonyms:2-(3,4-Dimethoxystyryl)quinoline;NSC59067;75903-25-2;2-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]quinoline;CHEMBL121001;NSC-59067;Quinoline, 2-(3,4-dimethoxystyryl);AKOS000277401;NCGC00181846-01;NCGC00181846-02;NCGC00181846-03;NCGC00181846-04;NCGC00181846-05;NCGC00181846-06;NCGC00181846-07;NCGC00181846-08;NCGC00181846-09;NCGC00181846-10;2-[2-(3,4-dimethoxyphenyl)vinyl]quinoline;2-[(E)-2-(3,4-dimethoxyphenyl)vinyl]quinoline;AB01307321-01;AT-051/40856709;Z46024317

Chemical Property of 2-(3,4-Dimethoxystyryl)quinoline

Chemical Property:

• Vapor Pressure: 4.04E-08mmHg at 25°C
• Refractive Index: 1.672
• Boiling Point: 457.5 °C at 760 mmHg
• Flash Point: 164 °C
• Density: 1.174 g/cm³
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 291.125928785
• Heavy Atom Count: 22
• Complexity: 370

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C=CC2=NC3=CC=CC=C3C=C2)OC
• Isomeric SMILES: COC1=C(C=C(C=C1)/C=C/C2=NC3=CC=CC=C3C=C2)OC

Technology Process of 2-(3,4-Dimethoxystyryl)quinoline

There total 1 articles about 2-(3,4-Dimethoxystyryl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-methylquinoline (91-63-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3',4'-dimethoxystyryl)quinoline (75903-25-2)

Guidance literature:

With zinc(II) chloride; at 150 ℃; Inert atmosphere;

DOI:10.1002/chem.201102438

Reference yield: 91.0%

2-(3',4'-dimethoxystyryl)quinoline (75903-25-2) → 2-(3,4-dimethoxy-β-phenethyl)-1,2,3,4-tetrahydroquinoline (104967-54-6)

Guidance literature:

With C₂₁H₁₃BF₈; hydrogen; In ⁽²⁾H₈-toluene; at 105 ℃; for 17h; under 3040.2 Torr; Inert atmosphere; Cooling with liquid nitrogen;

DOI:10.1002/chem.201102438

Reference yield:

methanol (67-56-1) + 2-(3',4'-dimethoxystyryl)quinoline (75903-25-2) → 2-[2-(3,4-dimethoxyphenyl)ethyl]-1-methyl-1,2,3,4-tetrahydroquinolineanol (104967-55-7,442-33-1)

Guidance literature:

With platinum(IV) oxide; hydrogen; at 20 ℃; for 240h;

DOI:10.21577/0103-5053.20180145

upstream raw materials:

2-methylquinoline

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

2-(3,4-dimethoxy-β-phenethyl)-1,2,3,4-tetrahydroquinoline

2-[2-(3,4-dimethoxyphenyl)ethyl]-1-methyl-1,2,3,4-tetrahydroquinolineanol

Refernces

• 1、 Gulakova,Sitin,Kuz'Mina,Fedorova. "Synthesis and structure of styryl-substituted azines". experimental part. p. 245 - 252. Retrieved 2011/05/03.