ALPHA-(4-CHLOROPHENYL)-4-PIPERIDINEMETHANOL

Base Information

• Chemical Name: ALPHA-(4-CHLOROPHENYL)-4-PIPERIDINEMETHANOL
• CAS No.: 36938-75-7
• Molecular Formula: C12H16ClNO
• Molecular Weight: 225.718
• Mol file: 36938-75-7.mol

Synonyms:(4-chlorophenyl)(piperidin-4-yl)methanol;4-Piperidyl-4'-chlorophenyl carbinol;(4-Chlorophenyl)(4-piperidinyl)methanol;(4-Chlor-phenyl)-[4]piperidyl-methanol;(4-chloro-phenyl)-[4]piperidyl-methanol;

Chemical Property of ALPHA-(4-CHLOROPHENYL)-4-PIPERIDINEMETHANOL

Chemical Property:

• Vapor Pressure: 4.94E-06mmHg at 25°C
• Boiling Point: 367oC at 760 mmHg
• Flash Point: 175.8oC
• PSA: 32.26000
• Density: 1.181g/cm3
• LogP: 2.70180

Purity/Quality:

99% ^*data from raw suppliers

a-(4-Chlorophenyl)-4-piperidinemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ALPHA-(4-CHLOROPHENYL)-4-PIPERIDINEMETHANOL

There total 5 articles about ALPHA-(4-CHLOROPHENYL)-4-PIPERIDINEMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(pyridin-4-yl)-(4-chlorophenyl)methanol (36938-77-9) → (4-chlorophenyl)(piperidin-4-yl)methanol (36938-75-7)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; for 0.5h; under 2280 Torr;

DOI:10.1021/jm0301033

Reference yield:

4-(4-chlorobenzoyl)pyridine (14548-48-2) → (4-chlorophenyl)(piperidin-4-yl)methanol (36938-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaBH₄ / ethanol / 0.5 h / Heating

2: 76 percent / H₂; aq. HCl / PtO₂ / ethanol / 0.5 h / 2280 Torr

With hydrogenchloride; sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm0301033

Reference yield:

4-(4-chlorobenzoyl)piperidine (53220-41-0) → (4-chlorophenyl)(piperidin-4-yl)methanol (36938-75-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; Inert atmosphere;

DOI:10.1039/c3cc45545a

upstream raw materials:

(pyridin-4-yl)-(4-chlorophenyl)methanol

4-(4-chlorobenzoyl)pyridine

4-(4-chlorobenzoyl)piperidine

Downstream raw materials:

4-(p-Chloro-α-hydroxybenzyl)-1-[3-(p-fluorobenzoyl)propyl]piperidine

Refernces

• 1、 Lyles-Eggleston,Altundas,Xia,Sikazwe,Fan,Yang,Li,Zhang,Zhu,Schmidt,Vanase-Frawley,Shrihkande,Villalobos,Borne,Ablordeppey. "Design, Synthesis, and Evaluation of Metabolism-Based Analogues of Haloperidol Incapable of Forming MPP+-like Species". . p. 497 - 508. Retrieved 2007/10/03.