2-BroMo-4-Methoxy-1-Methyl-benzene

Base Information

• Chemical Name: 2-BroMo-4-Methoxy-1-Methyl-benzene
• CAS No.: 36942-56-0
• Molecular Formula: C8H9BrO
• Molecular Weight: 201.063
• Hs Code.: 2909309090
• Mol file: 36942-56-0.mol

Synonyms:3-Brom-4-methyl-anisol;2-Bromo-4-methoxytoluene;3-Bromo-4-methylanisole;2-Brom-4-methoxy-toluol;4-METHOXY-2-BROMO TOLUENE;

Chemical Property of 2-BroMo-4-Methoxy-1-Methyl-benzene

Chemical Property:

• Melting Point: 144-145.5℃
• Boiling Point: 224.7±20.0℃ (760 Torr)
• Flash Point: 101.8±7.8℃
• PSA: 9.23000
• Density: 1.378±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 2.76610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

2-Bromo-4-methoxy-1-methylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-4-Methoxy-1-Methyl-benzene

There total 14 articles about 2-BroMo-4-Methoxy-1-Methyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxybenzyl Co(III)(dmgH)2py (42194-65-0) + bromine (7726-95-6) → 3-bromo-4-methylanisole (36942-56-0)

Guidance literature:

In chloroform; a solution of one or two equivalents of halogen added dropwise to a solution of organocobaloxime at room temperature under nitrogen in the dark; NMR, UV;

Reference yield: 100.0%

→ 3-bromo-4-methylanisole (36942-56-0)

Guidance literature:

With bromine; In chloroform; Ambient temperature;

DOI:10.1246/cl.1987.701

Reference yield: 93.0%

3-bromo-p-cresol (60710-39-6) + dimethyl sulfate (77-78-1) → 3-bromo-4-methylanisole (36942-56-0)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1002/anie.201801130

upstream raw materials:

3-bromo-p-cresol

dimethyl sulfate

5-methoxy-o-toluidine

p-methylanizole

Downstream raw materials:

2-bromo-1-(bromomethyl)-4-methoxybenzene

(5-methoxy-2-methylphenyl)boronic acid

N-(7-(5-methoxy-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide

Refernces

• 1、 Zhou, Zongtao,Cai, Zongyu,Zhang, Congzi,Yang, Benhui,Chen, Lianru,He, Yepu,Zhang, Luyong,Li, Zheng. "Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold". . . Retrieved 2022/01/24.
• 2、 Dherbassy, Quentin,Djukic, Jean-Pierre,Wencel-Delord, Joanna,Colobert, Fran?oise. "Two Stereoinduction Events in One C?H Activation Step: A Route towards Terphenyl Ligands with Two Atropisomeric Axes". supporting information. p. 4668 - 4672. Retrieved 2018/03/21.