1,2-Diamino-3,5-dinitrobenzene

Base Information

• Chemical Name: 1,2-Diamino-3,5-dinitrobenzene
• CAS No.: 3694-51-7
• Molecular Formula: C6H6N4O4
• Molecular Weight: 198.138
• Hs Code.: 2921590090
• Mol file: 3694-51-7.mol

Synonyms:3,5-dinitro-o-phenylenediamine;3,5-dinitrobenzene-1,2-diamine;3.5-Dintro-phenylendiamin-(1.2);3,5-Dinitro-o-phenylendiamin;3.5-Dinitro-1.2-diamino-benzol;

Chemical Property of 1,2-Diamino-3,5-dinitrobenzene

Chemical Property:

• PSA: 143.68000
• LogP: 2.87620

Purity/Quality:

95% ^*data from raw suppliers

3,5-Dinitro-1,2-phenylenediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dinitro-o-phenylenediamine is used as a reactant in the synthetic preparation of arylaminoquinoxalines and determines their activities as anticancer agents in human cancer cell lines, and their inhibition of human and bacterial dihydrofolate reductases and thymidylate synthases.

Technology Process of 1,2-Diamino-3,5-dinitrobenzene

There total 12 articles about 1,2-Diamino-3,5-dinitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

picramide (489-98-5) → 2-amino-3,5-dinitrophenylamine (3694-51-7)

Guidance literature:

With ammonium hydroxide; hydrogen sulfide; In ethanol; at 45 - 50 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2007.03.035

Reference yield:

→ 2-amino-3,5-dinitrophenylamine (3694-51-7)

Guidance literature:

With hydrogen iodide;

DOI:10.1021/ja01583a047

Reference yield:

4,6-dinitro-2,1,3-benzoselenadiazole (3955-45-1) → 2-amino-3,5-dinitrophenylamine (3694-51-7)

Guidance literature:

With hydrogenchloride; hydrogen iodide; at 20 ℃; for 2h; Yield given;

DOI:10.1055/s-1992-26359

upstream raw materials:

picramide

2-bromo-3,5-dinitro-aniline

4,6-dinitrobenzofuroxan

4,6-dinitro-2,1,3-benzoselenadiazole

Downstream raw materials:

6,8-dinitro-3-phenylquinoxalin-2(1H)one

5,7-dinitro-3-phenylquinoxalin-2(1H)one

4,6-dinitro-1-(2',4',6'-trinitrophenyl)benzotriazole

2-methyl-4,6-dinitro-1-(2',4',6'-trinitrophenyl)benzimidazole

Refernces

• 1、 Flippen-Anderson, Judith L.,Gilardi, Richard D.,Pitt, Adrian M.,Wilson, William S.. "Synthesis and Explosive Properties of Benzotriazoles". . p. 513 - 524. Retrieved 2007/10/02.