N-Benzyl-4-fluoroaniline Hydrochloride

Base Information

• Chemical Name: N-Benzyl-4-fluoroaniline Hydrochloride
• CAS No.: 370-77-4
• Molecular Formula: C13H12FN
• Molecular Weight: 201.243
• Mol file: 370-77-4.mol

Synonyms:BENZENEMETHANAMINE, N-(4-FLUOROPHENYL)-;N-Benzyl-4-fluoroaniline Hydrochloride;

Chemical Property of N-Benzyl-4-fluoroaniline Hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 3.51080

Purity/Quality:

98%min ^*data from raw suppliers

Benzenemethanamine,N-(4-fluorophenyl)- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Benzyl-4-fluoroaniline is an impurity of Ezetimibe (E975000), an antihyperlipoproteinemic agent and a cholesterol absorption inhibitor.

Technology Process of N-Benzyl-4-fluoroaniline Hydrochloride

There total 43 articles about N-Benzyl-4-fluoroaniline Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-fluoroaniline (371-40-4) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyl-p-fluoroaniline (370-77-4)

Guidance literature:

With chloro(η⁵-pentamethylcyclopentadienyl)(L-prolinato)iridium(III); In toluene; at 95 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol303075h

Reference yield: 99.0%

benzaldehyde (100-52-7) + 4-fluoroaniline (371-40-4) → N-benzyl-p-fluoroaniline (370-77-4)

Guidance literature:

With diphenylsilane; N,N,N,N,N,N-hexamethylphosphoric triamide; dibutyltin chloride; In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1039/b610614e

Reference yield: 99.0%

(E)-N-benzylidene-4-fluorobenzenamine (83306-62-1) → N-benzyl-p-fluoroaniline (370-77-4)

Guidance literature:

With ethanol; calcium; for 0.166667h; Heating;

upstream raw materials:

N-benzylidene-4-fluoroaniline

benzyl chloride

4-fluoroaniline

N-<4-Rhodan-benzyliden>-4-fluor-anilin

Downstream raw materials:

N-benzylidene-4-fluoroaniline

Benzyl-(4-fluoro-phenyl)-trifluoromethyl-amine

N-allyl-N-benzyl-4-fluoroaniline

(E)-N-benzylidene-4-fluorobenzenamine

Refernces

• 1、 Ganwir, Prerna,Chaturbhuj, Ganesh. "Sulfated polyborate: A dual catalyst for the reductive amination of aldehydes and ketones by NaBH4". supporting information. . Retrieved 2021/05/19.
• 2、 Fan, Qing-Hua,Liu, Xintong,Luo, Zhenli,Pan, Yixiao,Xu, Lijin,Yang, Ji,Yao, Zhen,Zhang, Xin. "BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant". supporting information. p. 5205 - 5211. Retrieved 2021/07/29.