2-FLUORO-4-HYDRAZINYL BENZENESULPHONAMIDE

Base Information

• Chemical Name: 2-FLUORO-4-HYDRAZINYL BENZENESULPHONAMIDE
• CAS No.: 370874-64-9
• Molecular Formula: C6H8FN3O2S
• Molecular Weight: 205.21000
• Mol file: 370874-64-9.mol

Synonyms:2-fluoro-4-hydrazinobenzenesulfonamide;2-FLUORO-4-HYDRAZINYL BENZENESULPHONAMIDE;2-fluoro-4-hydrazino-1-benzenesulfonamide;

Chemical Property of 2-FLUORO-4-HYDRAZINYL BENZENESULPHONAMIDE

Chemical Property:

• Boiling Point: 410.1±55.0 °C(Predicted)
• PKA: 10.18±0.60(Predicted)
• PSA: 106.59000
• Density: 1.588±0.06 g/cm3(Predicted)
• LogP: 2.31310

Purity/Quality:

98% ^*data from raw suppliers

2-fluoro-4-hydrazinylbenzenesulfonamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-4-HYDRAZINYL BENZENESULPHONAMIDE

There total 3 articles about 2-FLUORO-4-HYDRAZINYL BENZENESULPHONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,4-difluoro-1-benzenesulfonamide (13656-60-5) → 2-Fluoro-4-Hydrazino-Benzenesulfonamide (370874-64-9)

Guidance literature:

With hydrazine; In acetonitrile; for 6h; Heating;

DOI:10.1021/jm020563g

Reference yield:

1,3-Difluorobenzene (372-18-9) → 2-Fluoro-4-Hydrazino-Benzenesulfonamide (370874-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / ClSO₃H / 4 h / 0 °C

2: 53 percent / aq. NH₃ / dioxane / 6 h / 0 °C

3: 73 percent / NH₂NH₂ / acetonitrile / 6 h / Heating

With chlorosulfonic acid; ammonium hydroxide; hydrazine; In 1,4-dioxane; acetonitrile;

DOI:10.1021/jm020563g

Reference yield:

2,4-difluorobenzene-1-sulfonyl chloride (13918-92-8) → 2-Fluoro-4-Hydrazino-Benzenesulfonamide (370874-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / aq. NH₃ / dioxane / 6 h / 0 °C

2: 73 percent / NH₂NH₂ / acetonitrile / 6 h / Heating

With ammonium hydroxide; hydrazine; In 1,4-dioxane; acetonitrile;

DOI:10.1021/jm020563g

upstream raw materials:

2,4-difluoro-1-benzenesulfonamide

1,3-Difluorobenzene

2,4-difluorobenzene-1-sulfonyl chloride

Downstream raw materials:

1-(3-chloro-4-methylphenyl)-ethanone

Refernces

• 1、 -. "2-Fluorobenzenesulfonyl compounds for the treatment of inflammation". . . Retrieved 2008/06/13.