N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE

Base Information

• Chemical Name: N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE
• CAS No.: 375824-96-7
• Molecular Formula: C10H15N3OS
• Molecular Weight: 225.315
• Hs Code.: 2934200090
• Mol file: 375824-96-7.mol

Synonyms:2-amino-6-propionylamino-4,5,6,7-tetrahydro Benzothiazole;

Chemical Property of N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 502.879oC at 760 mmHg
• Flash Point: 257.932oC
• PSA: 96.25000
• Density: 1.269g/cm3
• LogP: 2.08090
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE

There total 4 articles about N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

thiourea (17356-08-0) + 4-propanoamidocyclohexanone (1044921-37-0) → 2-amino-6-(propionylamino)-4,5,6,7-tetrahydrobenzothiazole (375824-96-7)

Guidance literature:

4-propanoamidocyclohexanone; With hydrogen bromide; In ethyl acetate; at 20 ℃; for 0.25h; Green chemistry;

With dihydrogen peroxide; In ethyl acetate; at 60 ℃; for 5h; Green chemistry;

thiourea; In ethyl acetate; for 4h; Reflux; Green chemistry;

Reference yield:

2-amino-6-propionylamino-4,5,6,7-tetrahydrobenzothiazole hydrobromide → 2-amino-6-(propionylamino)-4,5,6,7-tetrahydrobenzothiazole (375824-96-7)

Guidance literature:

With sodium hydroxide; In water; at 5 - 10 ℃;

Reference yield:

p-hydroxycyclohexylamine (6850-65-3) → 2-amino-6-(propionylamino)-4,5,6,7-tetrahydrobenzothiazole (375824-96-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere; Reflux; Green chemistry

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium bromide / dichloromethane / 0.25 h / 0 °C / Green chemistry

2.2: 6 h / Green chemistry

3.1: hydrogen bromide / ethyl acetate / 0.25 h / 20 °C / Green chemistry

3.2: 5 h / 60 °C / Green chemistry

3.3: 4 h / Reflux; Green chemistry

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydrogen bromide; triethylamine; sodium bromide; In dichloromethane; ethyl acetate;

upstream raw materials:

p-hydroxycyclohexylamine

4-propionamidocyclohexanol

thiourea

4-propanoamidocyclohexanone

Downstream raw materials:

C₂₀H₃₂N₆S₂

(+)-2-amino-6-propionamidotetrahydrobenzothiazole

(S)?2?amino?6?propionamido?4,5,6,7?tetrahydrobenzothiazole

2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF PRAMIPEXOLE AND NEW ANHYDROUS FORMS OF ITS DIHYDROCHLORIDE". Page/Page column 4. . Retrieved 2009/04/24.