3-CHLORO-2,4-DIFLUOROANILINE 99

Base Information

• Chemical Name: 3-CHLORO-2,4-DIFLUOROANILINE 99
• CAS No.: 2613-34-5
• Molecular Formula: C6H4ClF2N
• Molecular Weight: 163.554
• Hs Code.: 2921420090
• Mol file: 2613-34-5.mol

Synonyms:Aniline,3-chloro-2,4-difluoro- (6CI,8CI);2,4-Difluoro-3-chloroaniline;NSC 10276;

Chemical Property of 3-CHLORO-2,4-DIFLUOROANILINE 99

Chemical Property:

• Vapor Pressure: 0.0996mmHg at 25°C
• Melting Point: 60-62 °C
• Refractive Index: 1.543
• Boiling Point: 222.811 °C at 760 mmHg
• PKA: 2.21±0.10(Predicted)
• Flash Point: 88.553 °C
• PSA: 26.02000
• Density: 1.459 g/cm³
• LogP: 2.78160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-2,4-difluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-2,4-DIFLUOROANILINE 99

There total 3 articles about 3-CHLORO-2,4-DIFLUOROANILINE 99 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-difluoro-3-chloro-nitrobenzene (3847-58-3) → 2,4-difluoro-3-chloro-aniline (2613-34-5)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In diethyl ether; at 40 ℃; for 0.5h;

DOI:10.1016/S0960-894X(03)00057-X

Reference yield:

tin(II)chloride dihydrate + 2,4-difluoro-3-chloro-nitrobenzene (3847-58-3) → 2,4-difluoro-3-chloro-aniline (2613-34-5)

Guidance literature:

In hydrogenchloride; water;

Reference yield:

→ 2,4-difluoro-3-chloro-aniline (2613-34-5)

Guidance literature:

/BRN= 3237513/;

DOI:10.1021/ja01510a021

upstream raw materials:

2,4-difluoro-3-chloro-nitrobenzene

Downstream raw materials:

3-chloro-2,4-difluorophenol

2-bromo-5-chloro-4,6-difluoroaniline

N-(3-chloro-2,4-difluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazoline-4-amine

2,4-difluorophenylamine

Refernces

• 1、 -. "Benzo[f]naphthyridine derivatives, their preparation and compositions containing them". . . Retrieved 2008/06/13.