Tenofovir alafenamide monofumarate

Base Information

• Chemical Name: Tenofovir alafenamide monofumarate
• CAS No.: 379270-38-9
• Molecular Formula: C21H29N6O5P.C4H4O4
• Molecular Weight: 592.53800
• European Community (EC) Number: 695-673-6
• UNII: LH74NEA26W
• Mol file: 379270-38-9.mol

Synonyms:Tenofovir impurity;GS-7339 monofumarate;1422343-76-7;Tenofovir alafenamide monofumarate;isopropyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate fumarate;LH74NEA26W;379270-38-9;SCHEMBL16402293;Tenofovir alafenamide fumarate (1;EX-A3379;L-Alanine, N-((R)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester, (2E)-2-butenedioate (1:1)

Chemical Property of Tenofovir alafenamide monofumarate

Chemical Property:

• PSA: 227.89000
• LogP: 3.65680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 14
• Exact Mass: 592.20466365
• Heavy Atom Count: 41
• Complexity: 799

Purity/Quality:

98%min ^*data from raw suppliers

GS-7340Fumarate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3.C(=C/C(=O)O)\C(=O)O
• Uses: Tenofovir alafenamide fumarate is a newer, more effective prodrug used in combination with FTC that has recently been approved for the prevention of HIV transmission through the rectum. It is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.