5-methoxy-1-naphthonitrile

Base Information

• Chemical Name: 5-methoxy-1-naphthonitrile
• CAS No.: 3813-01-2
• Molecular Formula: C12H9NO
• Molecular Weight: 183.20600
• Hs Code.: 2926909090
• Mol file: 3813-01-2.mol

Synonyms:5-methoxynaphthalene-1-carbonitrile;1-Cyano-5-Methoxy-naphthalene;

Chemical Property of 5-methoxy-1-naphthonitrile

Chemical Property:

• PSA: 33.02000
• LogP: 2.72008

Purity/Quality:

95% ^*data from raw suppliers

5-Methoxy-1-naphthonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methoxy-1-naphthonitrile

There total 5 articles about 5-methoxy-1-naphthonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Methoxy-3,4-dihydronaphthalene-1-carbonitrile (98218-37-2) → 1-cyano-5-methoxynaphthalene (3813-01-2)

Guidance literature:

With palladium on activated charcoal; sulfur; at 190 - 200 ℃; for 2h; Yield given;

DOI:10.1021/ja00102a028

Reference yield:

1-iodo-5-methoxynaphthalene (61735-51-1) + potassium ferrocyanide → 1-cyano-5-methoxynaphthalene (3813-01-2)

Guidance literature:

With sodium carbonate; palladium diacetate; In ISOPROPYLAMIDE; at 20 - 120 ℃; for 3h;

Reference yield:

5-Methoxy-1-tetralone (33892-75-0) → 1-cyano-5-methoxynaphthalene (3813-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BF₃*Et₂O, 2.) pyridine, POCl₃ / 1.) a) 60 deg C, 2 h, b) 90 deg C, 2 h, 2.) heating

2: sulfur, 5percent Pd/C / 2 h / 190 - 200 °C

With pyridine; palladium on activated charcoal; boron trifluoride diethyl etherate; sulfur; trichlorophosphate;

DOI:10.1021/ja00102a028

upstream raw materials:

5-Methoxy-3,4-dihydronaphthalene-1-carbonitrile

5-Bromo-1-cyanonaphthalene

methyl iodide

5-Methoxy-1-tetralone

Downstream raw materials:

5-Methoxynaphthalene-1-carbaldehyde

5-Cyano-2-naphthol

Refernces

• 1、 -. "PYRROLIDINE INHIBITORS OF IAP". Page/Page column 69. . Retrieved 2008/06/13.
• 2、 Schuster, Ingeborg I.. "13C NMR investigation of electronic interactions in 5-substituted 1-naphthonitriles". . p. 301 - 310. Retrieved 2007/10/03.