4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

Base Information

• Chemical Name: 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine
• CAS No.: 383865-57-4
• Molecular Formula: C12H15N3O2S
• Molecular Weight: 265.336
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80464823
• Wikidata: Q82290331
• Mol file: 383865-57-4.mol

Synonyms:4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine;383865-57-4;2-AMINO-4-METHOXY-7-MORPHOLINOBENZO[D]THIAZOLE;4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-amine;SCHEMBL2824784;SCHEMBL2828410;DTXSID80464823;DOIKFFGWUPLXGA-UHFFFAOYSA-N;CS-M0530;MFCD18642707;AKOS016007104;PB24422;DS-17729;P12429;2-amino-4-methoxy-7-morpholin-4-yl-benzothiazol;A873851;4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine;4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine

Chemical Property of 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

Chemical Property:

• PSA: 89.58000
• LogP: 1.71880
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 265.08849790
• Heavy Atom Count: 18
• Complexity: 289

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Amino-4-methoxy-7-morpholinobenzo[d]thiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C2C(=C(C=C1)N3CCOCC3)SC(=N2)N

Technology Process of 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

There total 9 articles about 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine (383865-57-4) + 5-methyl-thiophene-2-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Guidance literature:

Reference yield: 95.0%

(2-methoxy-5-morpholin-4-yl-phenyl)thiourea (383870-59-5) → 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine (383865-57-4)

Guidance literature:

(2-methoxy-5-morpholin-4-yl-phenyl)thiourea; With hydrogen bromide; acetic acid; In ethyl acetate; at 80 - 100 ℃; for 0.2h;

With dimethyl sulfoxide; In ethyl acetate; for 4h; Further stages; Heating;

DOI:10.1016/j.ejmech.2021.113214

Reference yield: 73.0%

1-benzoyl-3-(2-methoxy-5-morpholin-4-yl-phenyl)thiourea (383870-86-8) → 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine (383865-57-4)

Guidance literature:

1-benzoyl-3-(2-methoxy-5-morpholin-4-yl-phenyl)thiourea; With methanol; sodium methylate;

With bromine; In chloroform;

DOI:10.1155/2017/4852537

upstream raw materials:

(2-methoxy-5-morpholin-4-yl-phenyl)thiourea

4-bromo-1-methoxy-2-nitrobenzene

4-(4-methoxy-3-nitrophenyl)morpholine

2-methoxy-5-morpholin-4-ylaniline

Downstream raw materials:

phenyl (4-methoxy-7-morpholin-4-yl-benzo[d]thiazol-2-yl)carbamate

2-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-4-chloromethyl-benzamide

benzyl-methyl-amine

Refernces

• 1、 Yuan, Gengyang,Jankins, Tanner C.,Patrick, Christopher G.,Philbrook, Phaethon,Sears, Olivia,Hatfield, Stephen,Sitkovsky, Michail,Vasdev, Neil,Liang, Steven H.,Ondrechen, Mary Jo,Pollastri, Michael P.,Jones, Graham B.. "Fluorinated adenosine A2A receptor antagonists inspired by preladenant as potential cancer immunotherapeutics". . . Retrieved 2018/10/20.
• 2、 -. "Cyclization process for substituted benzothiazole derivatives". Page/Page column 7. . Retrieved 2008/06/13.