Technology Process of 8-Dodecyn-1-ol, acetate
There total 12 articles about 8-Dodecyn-1-ol, acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) Br2, 2) aq.KOH / 1) CCl4, r.t., 2) 135-145 deg C, 4 h
2: 86.2 percent / conc.H2SO4 / 4 h / Heating
3: 96 percent / LAH / diethyl ether / 2 h / Ambient temperature
4: 90.6 percent / PPTS / CH2Cl2 / 4 h / Ambient temperature
5: 1) n-BuLi, 2) HMPT / 1) THF, hexane, 10 deg C, 2) <25 deg C, 0.5 h
6: 83 percent / AcOH
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; bromine; pyridinium p-toluenesulfonate; acetic acid;
In
diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: n-PrLi / diethyl ether; tetrahydrofuran; benzene / -20 -> 20 deg C, 1.5 h
2: 1.) HMPA, 2.) KI / 1.) ether, THF, benzene, 20 deg C, 12 h, 2.) glacial acetic acid, reflux, 20 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; propyllithium; potassium iodide;
In
tetrahydrofuran; diethyl ether; benzene;
DOI:10.1007/BF00949490