N-1-(pyrid-2-yl)propane-1,3-diamine

Base Information

• Chemical Name: N-1-(pyrid-2-yl)propane-1,3-diamine
• CAS No.: 38585-73-8
• Molecular Formula: C8H13N3
• Molecular Weight: 151.20900
• Mol file: 38585-73-8.mol

Synonyms:N1-(pyridin-2-yl)propyl-1,3-diamine;N-(2-pyridinyl)-1,3-propanediamine;N-(pyridin-2-yl)propane-1,3-diamine;N-(2-pyridinyl)-1,3-propandiamine;2-(3-aminopropylamino)pyridine;N-1-(pyrid-2-yl)propane-1,3-diamine;N-(3-AMINOPROPYL)PYRIDIN-2-AMINE;

Chemical Property of N-1-(pyrid-2-yl)propane-1,3-diamine

Chemical Property:

• PSA: 50.94000
• LogP: 1.61560

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-(3-aminopropyl)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-1-(pyrid-2-yl)propane-1,3-diamine

There total 9 articles about N-1-(pyrid-2-yl)propane-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-aminopyridine (504-29-0) + propan-1-ol-3-amine (156-87-6) → N-(2-pyridinyl)-1,3-propandiamine (38585-73-8)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; Py₂NPiPr₂; sodium t-butanolate; In tetrahydrofuran; diethylene glycol dimethyl ether; at 110 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200900548

Reference yield: 76.0%

2-bromo-pyridine (109-04-6) + Trimethylenediamine (109-76-2,54018-94-9) → N-(2-pyridinyl)-1,3-propandiamine (38585-73-8)

Guidance literature:

With pyridine; for 18h; Heating;

DOI:10.1021/ja973325x

Reference yield: 72.0%

2-bromo-pyridine (109-04-6) + Trimethylenediamine (109-76-2,54018-94-9) → N-(2-pyridinyl)-1,3-propandiamine (38585-73-8) + N1,N3-di(pyridin-2-yl)propan-1,3-diamine (136575-57-0)

Guidance literature:

In pyridine; for 3h; Heating; several substituted 2-halopyridines investigated;

DOI:10.1016/0223-5234(89)90006-8

upstream raw materials:

pyridine

2-bromo-pyridine

Trimethylenediamine

3-[2]pyridylamino-propionaldehyde oxime

Downstream raw materials:

N₁-(4-bromobenzyl)-N₁-(pyridin-2-yl)-propane-1,3-diamine

C₁₅H₁₆FN₃O

2-cyano-1-[2-(phenylthio)ethyl]-3-[3-(pyridin-2-ylamino)propyl]guanidine

N-(4-chlorobenzyl)-N-(pyridin-2-yl)-1,3-propanediamine

Refernces

• 1、 Geyer, Roland,Kaske, Melanie,Baumeister, Paul,Buschauer, Armin. "Synthesis and functional characterization of imbutamine analogs as histamine H3 and H4 receptor ligands". . p. 77 - 88. Retrieved 2014/03/21.
• 2、 Blank, Benoit,Michlik, Stefan,Kempe, Rhett. "Synthesis of selectively mono-N-arylated aliphatic diamines via iridium-catalyzed amine alkylation". experimental part. p. 2903 - 2911. Retrieved 2010/03/25.