Phenol, 3-amino-, 4-methylbenzenesulfonate (ester)

Base Information

• Chemical Name: Phenol, 3-amino-, 4-methylbenzenesulfonate (ester)
• CAS No.: 3865-15-4
• Molecular Formula: C13H13NO3S
• Molecular Weight: 263.317
• Hs Code.: 2922199090
• Mol file: 3865-15-4.mol

Synonyms:p-Toluolsulfonsaeure-(3-amino-phenylester);3-aminophenyl tosylate;O-tosyl-m-aminophenol;Toluol-4-sulfonsaeure-(3-amino-phenylester);m-Aminophenyl Tosylate;toluene-4-sulfonic acid-(3-amino-phenyl ester);

Chemical Property of Phenol, 3-amino-, 4-methylbenzenesulfonate (ester)

Chemical Property:

• Melting Point: 92 - 95°C
• PSA: 77.77000
• LogP: 4.00690

Purity/Quality:

95% ^*data from raw suppliers

m-AminophenylTosylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: m-Aminophenyl Tosylate is a reactant used in the synthesis of 2-methyl-5-(2,3,4,5,6-pentafluorophenyl)benzothiazole and 4-[(2'',3'',4'',5'',6''-pentafluoro-1,1''-biphenyl-3-yl)amino]benzonitrile.

Technology Process of Phenol, 3-amino-, 4-methylbenzenesulfonate (ester)

There total 3 articles about Phenol, 3-amino-, 4-methylbenzenesulfonate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.9%

p-toluenesulfonyl chloride (98-59-9) + m-Hydroxyaniline (591-27-5) → 3-aminophenyl tosylate (3865-15-4)

Guidance literature:

m-Hydroxyaniline; With sodium hydroxide; In acetone; at 20 - 23 ℃; for 2h;

p-toluenesulfonyl chloride; In acetone; for 2.5h; Temperature; Reagent/catalyst;

Reference yield:

3-nitrophenyl 4-methylbenzenesulfonate (3899-90-9) → 3-aminophenyl tosylate (3865-15-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jo00014a009

Reference yield:

→ 3-aminophenyl tosylate (3865-15-4)

Guidance literature:

With hydrogenchloride; tin(ll) chloride;

DOI:10.1039/jr9300001981

upstream raw materials:

3-nitrophenyl 4-methylbenzenesulfonate

p-toluenesulfonyl chloride

m-Hydroxyaniline

Downstream raw materials:

diisopropyl 3-aminophenylphosphonate

C₂₁H₂₉NO₉S₃

3-aminophenylboronic acid pinacolate

3-((4-(tert-butyl)phenyl)amino)benzonitrile

Refernces

• 1、 -. "A heat-sensitive structure containing sulfonylurea preparation method of the developer (by machine translation)". Paragraph 0036; 0037; 0043; 0044; 0049; 0050; 0051-0054. . Retrieved 2017/07/20.
• 2、 Goswami,Mahapatra,Mukherjee. "Hydrogen Bonding Induced Solid State Supramolecular Assemblies of Selective O-Tosyl and N-Tosyl Derivatives of 3-Aminophenol". . p. 773 - 775. Retrieved 2007/10/03.