Phosphonium, triphenyl(2-pyridinylmethyl)-, chloride

Base Information

• Chemical Name: Phosphonium, triphenyl(2-pyridinylmethyl)-, chloride
• CAS No.: 38700-15-1
• Molecular Formula: C24H21NP.Cl
• Molecular Weight: 389.864
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60453659
• Mol file: 38700-15-1.mol

Synonyms:38700-15-1;Phosphonium, triphenyl(2-pyridinylmethyl)-, chloride;(2-Pyridinylmethyl)triphenylphosphonium chloride;Triphenyl(pyridin-2-ylmethyl)phosphonium chloride;triphenyl(pyridin-2-ylmethyl)phosphanium;chloride;triphenyl(2-pyridylmethyl)phosphonium chloride;triphenyl-2-picolylphosphonium chloride;SCHEMBL136776;DTXSID60453659;IUNXOGIHFLDANL-UHFFFAOYSA-M;MFCD16877717;AKOS017345062;FD10615;2-Picolyl triphenyl phosphonium chloride;FT-0699388;(2-pyridyl)methyltriphenylphosphonium chloride;(2-pyridylmethyl)triphenylphosphonium chloride;triphenyl 2-pyridylmethyl phosphonium chloride;[(2-pyridyl)methyl]triphenylphosphonium chloride

Chemical Property of Phosphonium, triphenyl(2-pyridinylmethyl)-, chloride

Chemical Property:

• PSA: 26.48000
• LogP: 1.57970
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 389.1100144
• Heavy Atom Count: 27
• Complexity: 359

Purity/Quality:

99.90% ^*data from raw suppliers

(2-PYRIDINYLMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)[P+](CC2=CC=CC=N2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-]

Technology Process of Phosphonium, triphenyl(2-pyridinylmethyl)-, chloride

There total 5 articles about Phosphonium, triphenyl(2-pyridinylmethyl)-, chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloromethylpyridine hydrochloride (6959-47-3) + triphenylphosphine (603-35-0) → Triphenyl-2-pyridylmethylphosphonium chloride hydrochloride (38700-15-1)

Guidance literature:

In N,N-dimethyl-formamide; at 140 ℃; for 20h;

DOI:10.1016/S0040-4039(01)90414-9

Reference yield: 95.0%

2-chloromethylpyridine hydrochloride (6959-47-3) + triphenylphosphine (603-35-0) → triphenyl-(2-pyridylmethyl)phosphonium chloride (38700-15-1)

Guidance literature:

2-chloromethylpyridine hydrochloride; With sodium carbonate; In water; at 20 ℃; for 0.5h;

triphenylphosphine; In toluene; for 24h; Reflux;

DOI:10.1021/acs.orglett.1c02968

Reference yield: 94.0%

2-chloromethylpyridine (4377-33-7) + triphenylphosphine (603-35-0) → triphenyl-(2-pyridylmethyl)phosphonium chloride (38700-15-1)

Guidance literature:

In 1,4-dioxane; for 24h; Heating;

DOI:10.1021/jm970351x

upstream raw materials:

2-chloromethylpyridine

triphenylphosphine

2-chloromethylpyridine hydrochloride

Downstream raw materials:

(R)-3-Acetoxymethyl-8-oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

2-styrylpyridine

2-((E)-2-{3-[(4-{[2-(furan-2-yl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazol-4-yl}ethenyl)pyridine

C₁₁H₉NO

Refernces

• 1、 Regnouf-de-Vains, Jean-Bernard,Lamartine, Roger. "Wittig reaction on calixarene upper rim. Access to conjugated bipyridyl and pyridyl podands". . p. 6311 - 6314. Retrieved 1996.
• 2、 Hu, Chen-Yu,Li, Xiang,Liang, Xin-Shen,Liu, Ning,Tian, Jun-Jie,Tu, Xian-Shuang,Wang, Xiao-Chen,Yang, Zhao-Ying. "Borane-Catalyzed Chemoselective and Enantioselective Reduction of 2-Vinyl-Substituted Pyridines". supporting information. p. 18452 - 18456. Retrieved 2020/08/21.
• 3、 -. "PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS". Paragraph 0147; 0148. . Retrieved 2013/07/05.