(Z)-N'-(4-(dimethylamino)benzylidene)isonicotinohydrazide

Base Information

• Chemical Name: (Z)-N'-(4-(dimethylamino)benzylidene)isonicotinohydrazide
• CAS No.: 13059-77-3
• Molecular Formula: C15H16 N4 O
• Molecular Weight: 268.318
• NSC Number: 47408
• Nikkaji Number: J1.026.715C
• Wikidata: Q76391474
• Mol file: 13059-77-3.mol

Synonyms:1262213-12-6;NSC47408;N'-[(1Z)-[4-(dimethylamino)phenyl]methylidene]pyridine-4-carbohydrazide;NSC-47408;AKOS024576034;SR-01000005765;SR-01000005765-1;F0364-0004;(Z)-N'-(4-(dimethylamino)benzylidene)isonicotinohydrazide;4-(Dimethylamino)benzaldehyde (4-pyridylcarbonyl)hydrazone

Chemical Property of (Z)-N'-(4-(dimethylamino)benzylidene)isonicotinohydrazide

Chemical Property:

• PSA: 57.59000
• Density: 1.12g/cm3
• LogP: 2.30240
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 268.13241115
• Heavy Atom Count: 20
• Complexity: 329

Purity/Quality:

99% ^*data from raw suppliers

4-PYRIDINECARBOXYLIC 4-(DIMETHYLAMINO)BENZYLIDENEHYDRAZIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)C=NNC(=O)C2=CC=NC=C2
• Isomeric SMILES: CN(C)C1=CC=C(C=C1)/C=N\NC(=O)C2=CC=NC=C2

Technology Process of (Z)-N'-(4-(dimethylamino)benzylidene)isonicotinohydrazide

There total 2 articles about (Z)-N'-(4-(dimethylamino)benzylidene)isonicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isoniazid (54-85-3,7640-37-1) + 4-dimethylamino-benzaldehyde (100-10-7) → isonicotinic acid (4-dimethylaminobenzylidene)hydrazide (13059-77-3)

Guidance literature:

at 60 ℃; for 0.333333h;

DOI:10.1021/cg400529s

Reference yield:

→ isonicotinic acid (4-dimethylaminobenzylidene)hydrazide (13059-77-3)

Guidance literature:

Isonicotinoylhydrazin, 4-Dimethylaminobenzaldehyd, Methylcellosolve, A. (Rueckfluss);

Reference yield: 84.0%

serin (302-84-1,83245-15-2) + isonicotinic acid (4-dimethylaminobenzylidene)hydrazide (13059-77-3) → N-(2-(4-(dimethylamino)phenyl)-4-(hydroxymethyl)-5-oxoimidazolidin-1-yl)isonicotinamide

Guidance literature:

In tetrahydrofuran; at 80 ℃; for 24h; Reflux;

upstream raw materials:

isoniazid

4-dimethylamino-benzaldehyde

Downstream raw materials:

2-(4-pyridyl)-5-(p-dimethylamino)phenyl-1,3,4-oxadiazole

{Ag((C₉H₁₁N)NNH(CO)C₅H₄N)NO₃}

{Ag((C₉H₁₁N)NNH(CO)C₅H₄N)ClO₄}

Refernces

• 1、 Montazerozohori,Masoudiasl,Doert, Th.. "Two new 1D zigzag Hg(II) nanostructure coordination polymers: Sonochemical synthesis, thermal study, crystal structure and Hirshfeld surface analysis". . p. 207 - 217. Retrieved 2016.
• 2、 Siddiqui, Shadab Miyan,Salahuddin, Attar,Azam, Amir. "Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold". . p. 411 - 416. Retrieved 2012.
• 3、 Trzesowska-Kruszynska, Agata. "Solvent-free and catalysis-free approach to the solid state in situ growth of crystalline isoniazid hydrazones". . p. 3892 - 3900. Retrieved 2013.
• 4、 Singirisetty, Triveni,Chilamakuru, Naresh Babu,Peraman, Ramalingam,Mallela, Vijaya Jyothi,Sana, Maheswari P.,Begum, Inthiyaz. "Design and Synthesis of 5-Oxoimidazolidine Derivatives in Search of Potent Antitubercular and Antifungal agents". . p. 441 - 451. Retrieved 2021/02/02.