ETHYL 3-METHYLQUINOXALINE-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 3-METHYLQUINOXALINE-2-CARBOXYLATE
• CAS No.: 3885-38-9
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23600
• Hs Code.: 2933990090
• Mol file: 3885-38-9.mol

Synonyms:ethyl 3-methylquinoxalin-2-carboxylate;2-ethoxycarbonyl-3-methylquinoxaline;3-methyl-quinoxaline-2-carboxylic acid ethyl ester;ethylmethylquinoxalinecarboxylate;2-methyl-3-ethoxycarbonylquinoxaline;Ethyl 3-methyl-2-quinoxalinecarboxylate;ethyl 3-methyl-quinoxaline-2-carboxylate;

Chemical Property of ETHYL 3-METHYLQUINOXALINE-2-CARBOXYLATE

Chemical Property:

• PSA: 52.08000
• LogP: 2.11490
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl3-Methyl-2-quinoxalinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 3-methyl-2-quinoxalinecarboxylate is an protected metabolite of Carbadox (C175825) an antimicrobial agents.

Technology Process of ETHYL 3-METHYLQUINOXALINE-2-CARBOXYLATE

There total 21 articles about ETHYL 3-METHYLQUINOXALINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-diazo-3-oxobutanoate (2009-97-4) + 1,2-diamino-benzene (95-54-5) → 2-methyl-3-ethoxycarbonylquinoxaline (3885-38-9)

Guidance literature:

With iron(III) trifluoromethanesulfonate; In water; at 70 ℃; for 3h; Reagent/catalyst; Solvent; Temperature; Green chemistry;

DOI:10.1002/adsc.201600503

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + 1,2-diamino-benzene (95-54-5) → 2-methyl-3-ethoxycarbonylquinoxaline (3885-38-9)

Guidance literature:

With 4-toluenesulfonyl azide; Porcine Pancreas Lipase; hemoglobin from bovine blood; In water; at 55 ℃; for 6h; Reagent/catalyst; regioselective reaction; Green chemistry; Enzymatic reaction;

DOI:10.1021/acs.orglett.0c01186

Reference yield: 90.0%

1,2-diamino-benzene (95-54-5) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → 2-methyl-3-ethoxycarbonylquinoxaline (3885-38-9)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 20 ℃; for 1h; Ionic liquid;

DOI:10.1016/j.tetlet.2010.05.099

upstream raw materials:

o-phenylenediamine hydrochloride

ethyl 2,3-dioxobutyrate

1,2-diamino-benzene

ethyl 2-chloro-3-oxo-butyrate

Downstream raw materials:

3-methylquinoxaline-2-hydrazide

2-methyl-3-ethoxycarbonylquinoxaline 1-N-oxide

2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide

3-methylquinoxaline-2-carbaldehyde

Refernces

• 1、 Platte, Simon,Korff, Marvin,Imberg, Lukas,Balicioglu, Ilker,Erbacher, Catharina,Will, Jonas M.,Daniliuc, Constantin G.,Karst, Uwe,Kalinin, Dmitrii V.. "Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors". . p. 3672 - 3690. Retrieved 2021/08/07.
• 2、 Li, Fengxi,Li, Zhengqiang,Tang, Xuyong,Wang, Chunyu,Wang, Lei,Wang, Zhi,Xu, Yaning. "A dual-protein cascade reaction for the regioselective synthesis of quinoxalines". supporting information. p. 3900 - 3904. Retrieved 2020/06/08.