1-[3,5-bis(1-hydroxyethyl)phenyl]ethanol

Base Information

• Chemical Name: 1-[3,5-bis(1-hydroxyethyl)phenyl]ethanol
• CAS No.: 37394-26-6
• Molecular Formula: C₁₂H₁₈O₃
• Molecular Weight: 210.273
• Mol file: 37394-26-6.mol

Synonyms:

Chemical Property of 1-[3,5-bis(1-hydroxyethyl)phenyl]ethanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3,5-bis(1-hydroxyethyl)phenyl]ethanol

There total 16 articles about 1-[3,5-bis(1-hydroxyethyl)phenyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,3,5-triacetylbenzene (779-90-8) → (S,S,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol (37394-26-6,143394-14-3,143394-15-4,143394-16-5,143394-17-6,147977-11-5,147977-12-6)

Guidance literature:

With C₃₀H₃₂ClN₂O₂RuS; hydrogen; potassium hydroxide; In 2,2,2-trifluoroethanol; at 40 ℃; for 24h; under 30402 Torr; stereoselective reaction; Autoclave;

DOI:10.1021/acs.orglett.8b00034

Reference yield: 90.0%

1,3,5-Triethynylbenzene (7567-63-7) → (S,S,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol (37394-26-6,143394-14-3,143394-15-4,143394-16-5,143394-17-6,147977-11-5,147977-12-6)

Guidance literature:

1,3,5-Triethynylbenzene; With trifluorormethanesulfonic acid; water; In 2,2,2-trifluoroethanol; at 60 ℃; for 72h; Inert atmosphere;

With chloro([(S,2S)-(?)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido)(mesitylene)ruthenium (II); hydrogen; potassium hydroxide; In 2,2,2-trifluoroethanol; at 40 ℃; for 24h; under 30003 Torr; Autoclave;

Reference yield: 90.0%

(R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate (143329-95-7) → (R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol (37394-26-6,143394-14-3,143394-15-4,143394-16-5,143394-17-6,147977-11-5,147977-12-6)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1021/jo00045a042

upstream raw materials:

1,3,5-triacetylbenzene

(S,S,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol triacetate

1,3,5-Triethynylbenzene

(R,S,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol diacetate

Downstream raw materials:

1,3,5-trivinylbenzene

1,3,5-Tris(1-bromaethyl)benzol

α,α',α''-trimethyl-1,3,5-benzenetrimethanol triacetate

(R,R,S)-α,α',α''-trimethyl-1,3,5-benzenetrimethanol monoacetate

Refernces

• 1、 Liu, Sensheng,Liu, Huan,Zhou, Haifeng,Liu, Qixing,Lv, Jinliang. "Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation". supporting information. p. 1110 - 1113. Retrieved 2018/02/23.