(3S,5S,8R,9S,10S,13S,14S,16R,17S)-17-(1-hydroxyethyl)-10,13-dimethyl-2 ,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenan threne-3,16-diol

Base Information

• Chemical Name: (3S,5S,8R,9S,10S,13S,14S,16R,17S)-17-(1-hydroxyethyl)-10,13-dimethyl-2 ,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenan threne-3,16-diol
• CAS No.: 2220-64-6
• Molecular Formula: C₂₁H₃₆O₃
• Molecular Weight: 336.515
• Mol file: 2220-64-6.mol

Synonyms:5a-Pregnane-3b,16a,20a-triol (7CI,8CI); NSC 72823

Chemical Property of (3S,5S,8R,9S,10S,13S,14S,16R,17S)-17-(1-hydroxyethyl)-10,13-dimethyl-2 ,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenan threne-3,16-diol

Chemical Property:

• Vapor Pressure: 5.57E-11mmHg at 25°C
• Melting Point: 254-256 °C
• Boiling Point: 474.1°Cat760mmHg
• PKA: 15.05±0.20(Predicted)
• Flash Point: 210.5°C
• PSA: 60.69000
• Density: 1.117g/cm³
• LogP: 3.35780

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S,5S,8R,9S,10S,13S,14S,16R,17S)-17-(1-hydroxyethyl)-10,13-dimethyl-2 ,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenan threne-3,16-diol

There total 17 articles about (3S,5S,8R,9S,10S,13S,14S,16R,17S)-17-(1-hydroxyethyl)-10,13-dimethyl-2 ,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenan threne-3,16-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (20R)-5β-pregnanetriol-(3β.16β.20) (1098-46-0,1165-35-1,2220-64-6,4025-57-4,4362-96-3,4362-97-4,25127-09-7,26551-02-0,26575-06-4,30343-90-9,31427-40-4,55253-66-2,55528-51-3,72984-71-5,98048-16-9,120708-84-1)

Guidance literature:

With chromium(VI) oxide; acetic acid; Hydrierung des Reaktionsprodukts in Eisessig an Platin und Erhitzen der Hydrierungsprodukte mit aethanol. KOH;

DOI:10.1021/ja01848a039

Reference yield:

→ (20R)-5β-pregnanetriol-(3β.16β.20) (1098-46-0,1165-35-1,2220-64-6,4025-57-4,4362-96-3,4362-97-4,25127-09-7,26551-02-0,26575-06-4,30343-90-9,31427-40-4,55253-66-2,55528-51-3,72984-71-5,98048-16-9,120708-84-1)

Guidance literature:

With chromium(VI) oxide; acetic acid; Hydrierung des Reaktionsprodukts in Eisessig an Platin und Erhitzen der Hydrierungsprodukte mit aethanol. KOH;

DOI:10.1021/ja01848a039

Reference yield:

Di-O-acetyl-dihydropseudosarsasapogenin (39636-36-7,65243-88-1,120707-87-1,120707-88-2) → (20R)-5β-pregnanetriol-(3β.16β.20) (1098-46-0,1165-35-1,2220-64-6,4025-57-4,4362-96-3,4362-97-4,25127-09-7,26551-02-0,26575-06-4,30343-90-9,31427-40-4,55253-66-2,55528-51-3,72984-71-5,98048-16-9,120708-84-1)

Guidance literature:

With chromium(VI) oxide; acetic acid; Hydrierung des Reaktionsprodukts in Eisessig an Platin und Erhitzen der Hydrierungsprodukte mit aethanol. KOH;

DOI:10.1021/ja01848a039

upstream raw materials:

3β,16α,20α_F-triacetoxy-5α-pregnane

(20S)-5α-pregnene-(16)-diol-(3β,20)

(3β,5α,16α)-16,17-epoxy-3-hydroxypregnan-20-one

3β-acetoxy-5α-pregn-16-en-20-one