2-(3-bromophenyl)-2-methyl-1,3-dioxolane

Base Information

• Chemical Name: 2-(3-bromophenyl)-2-methyl-1,3-dioxolane
• CAS No.: 39172-32-2
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Mol file: 39172-32-2.mol

Synonyms:3-bromopropiophenone ethylene acetal;

Chemical Property of 2-(3-bromophenyl)-2-methyl-1,3-dioxolane

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Boiling Point: 294.764oC at 760 mmHg
• Flash Point: 130.195oC
• PSA: 18.46000
• Density: 1.433g/cm3
• LogP: 2.66860

Purity/Quality:

95% ^*data from raw suppliers

2-(3-Bromo-phenyl)-2-methyl[1,3]dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-bromophenyl)-2-methyl-1,3-dioxolane

There total 4 articles about 2-(3-bromophenyl)-2-methyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethylene glycol (107-21-1) + 1-(3-Bromophenyl)ethanone (2142-63-4) → 2-(3-bromophenyl)-2-methyl-[1,3]dioxolane (39172-32-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating / reflux; water separator;

Reference yield:

1-(3-Bromophenyl)ethanone (2142-63-4) + trimethyl orthoformate (149-73-5) → 2-(3-bromophenyl)-2-methyl-[1,3]dioxolane (39172-32-2)

Guidance literature:

With lithium tetrafluoroborate; In ethylene glycol; at 95 ℃; for 3.5h; Inert atmosphere;

Reference yield:

1-(3-Bromophenyl)ethanone (2142-63-4) → 2-(3-bromophenyl)-2-methyl-[1,3]dioxolane (39172-32-2)

Guidance literature:

With toluene-4-sulfonic acid; In ethylene glycol; benzene;

upstream raw materials:

ethylene glycol

1-(3-Bromophenyl)ethanone

trimethyl orthoformate

Downstream raw materials:

1-(3-cyclopropylphenyl)ethan-1-one

2-(3-trimethylgermylphenyl)-2-methyl-1,3-dioxolane

3-carboxymethylacetophenone

[3-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-acetic acid

Refernces

• 1、 Grau, Brendan T.,Devine, Paul N.,DiMichele, Lisa N.,Kosjek, Birgit. "Chemo- and enantioselective routes to chiral fluorinated hydroxyketones using ketoreductases". . p. 4951 - 4954. Retrieved 2007.
• 2、 Bandeira, Pamela T.,Dalmolin, Mara C.,de Oliveira, Mariana M.,Nunes, Karine C.,Garcia, Francielle P.,Nakamura, Celso V.,de Oliveira, Alfredo R.M.,Piovan, Leandro. "Synthesis, Antioxidant Activity and Cytotoxicity of N-Functionalized Organotellurides". supporting information. p. 410 - 415. Retrieved 2019/01/04.