(Z)-2-(1H-Indol-3-yl)vinyl isocyanide

Base Information Edit

Chemical Name:(Z)-2-(1H-Indol-3-yl)vinyl isocyanide
CAS No.:61168-06-7
Molecular Formula:C11H8N2
Molecular Weight:168.198
Hs Code.:
Mol file:61168-06-7.mol

Synonyms:3-((Z)-2-Isocyano-vinyl)-1H-indole;Indolacrylisonitril;(Z)-3-(2-isocyanovinyl)-1H-indole;cis-indoyl vinyl isonitrile;

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Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-(1H-Indol-3-yl)vinyl isocyanide Edit

Chemical Property:

PSA：28.15000
LogP:2.59320

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (Z)-2-(1H-Indol-3-yl)vinyl isocyanide

There total 10 articles about (Z)-2-(1H-Indol-3-yl)vinyl isocyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 551-85-9,2922-69-2,4151-19-3,60802-29-1
Ribulose-5-phosphate

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 61168-06-7
(Z)-2-(3-Indolyl)vinyl Isocyanide

Guidance literature:: With iron(II) ammonium sulfate; α-ketoglutaric acid disodium salt dihydrate; Fe(II)-α-ketoglutarate-dependent dioxygenase WelI3; isonitrile synthase WelI₁; In glycerol; at 37 ℃; for 18h; Green chemistry; Enzymatic reaction;
DOI:10.1007/s12038-021-00156-4

Reference yield: 2.5%

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 41003-94-5
diethyl isocyanomethylphosphonate

: 61168-06-7
(Z)-2-(3-Indolyl)vinyl Isocyanide

Guidance literature:: diethyl isocyanomethylphosphonate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h;

Indole-3-carboxaldehyde; In tetrahydrofuran; at -78 - 3 ℃; for 22h; Darkness;
DOI:10.1021/jacs.5b10136

Reference yield:

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 61168-06-7
(Z)-2-(3-Indolyl)vinyl Isocyanide

Guidance literature:: With Ribulose-5-phosphate; ambiguine I₁ homologues of isonitrile synthase A; ambiguine I₂ homologues of isonitrile synthase A; ambiguine I₃ homologues of isonitrile synthase B; α-ketoglutarate; iron(II); Reagent/catalyst; Microbiological reaction; Enzymatic reaction;
DOI:10.1021/cb400681n