Technology Process of Carbamic acid, [6-(hydroxymethyl)-2-naphthalenyl]-, 2-propenyl ester
There total 4 articles about Carbamic acid, [6-(hydroxymethyl)-2-naphthalenyl]-, 2-propenyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-(((tert-butyldimethylsilyl)oxy)methyl)-2-naphthoic acid;
With
diphenylphosphoranyl azide; triethylamine;
In
toluene;
at 20 ℃;
allyl alcohol;
In
toluene;
at 85 ℃;
for 5h;
Further stages.;
DOI:10.1021/jo0158884
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: imidazole / tetrahydrofuran
1.2: 37 percent / NaHCO3 / tetrahydrofuran / 1 h
2.1: diphenylphosphoryl azide; Et3N / toluene / 20 °C
2.2: 49 percent / toluene / 5 h / 85 °C
With
1H-imidazole; diphenylphosphoranyl azide; triethylamine;
In
tetrahydrofuran; toluene;
2.1: Curtius rearrangement;
DOI:10.1021/jo0158884
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 94 percent / NaOH / H2O; methanol / 3 h
2.1: imidazole / tetrahydrofuran
2.2: 37 percent / NaHCO3 / tetrahydrofuran / 1 h
3.1: diphenylphosphoryl azide; Et3N / toluene / 20 °C
3.2: 49 percent / toluene / 5 h / 85 °C
With
1H-imidazole; sodium hydroxide; diphenylphosphoranyl azide; triethylamine;
In
tetrahydrofuran; methanol; water; toluene;
3.1: Curtius rearrangement;
DOI:10.1021/jo0158884
