5-Fluoroisoquinoline

Base Information

• Chemical Name: 5-Fluoroisoquinoline
• CAS No.: 394-66-1
• Molecular Formula: C9H6FN
• Molecular Weight: 147.152
• Hs Code.: 2933499090
• Mol file: 394-66-1.mol

Synonyms:5-Fluor-isochinolin;5-FLUORO-ISOQUINOLINE;Isoquinoline,5-fluoro;8-Fluor-isochinolin;

Chemical Property of 5-Fluoroisoquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 2.37390

Purity/Quality:

99%, ^*data from raw suppliers

5-fluoroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoroisoquinoline

There total 3 articles about 5-Fluoroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-hydroxyisoquinoline (2439-04-5) → 5-fluoroisoquinoline (394-66-1)

Guidance literature:

With N,N'-1,3-bis(2,6-diisopropylphenyl)-4,5-dihydro-2,2-difluoroimidazolidine; cesium fluoride; In 1,4-dioxane; at 23 - 110 ℃; for 24.5h; Inert atmosphere;

DOI:10.1021/op500121w

Reference yield: 48.0%

→ 5-fluoroisoquinoline (394-66-1)

Guidance literature:

With fluoride; In 1,4-dioxane; water; at 110 ℃; for 0.0833333h;

Reference yield:

→ 5-fluoroisoquinoline (394-66-1)

Guidance literature:

DOI:10.1021/ja01146a054

upstream raw materials:

5-hydroxyisoquinoline

Refernces

• 1、 Fujimoto, Teppei,Ritter, Tobias. "PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols". supporting information. p. 544 - 547. Retrieved 2015/03/05.