2-(4-Chlorophenyl)-2-oxoethyl acetate

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-2-oxoethyl acetate
• CAS No.: 39561-82-5
• Molecular Formula: C10H9ClO3
• Molecular Weight: 212.633
• Hs Code.: 2915390090
• Mol file: 39561-82-5.mol

Synonyms:2-acetoxy-1-(4-chlorophenyl)ethanone;2-acetoxy-4'-chloroacetophenone;chlorophenyloxoethylacetate;2-(4-Chlorophenyl)-2-oxoethyl acetate;

Chemical Property of 2-(4-Chlorophenyl)-2-oxoethyl acetate

Chemical Property:

• Vapor Pressure: 0.00034mmHg at 25°C
• Melting Point: 174-176oC
• Boiling Point: 319.4oC at 760 mmHg
• Flash Point: 137.1oC
• PSA: 43.37000
• Density: 1.255g/cm3
• LogP: 2.08580

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Chlorophenyl)-2-oxoethylAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Chlorophenyl)-2-oxoethyl acetate

There total 22 articles about 2-(4-Chlorophenyl)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + para-chloroacetophenone (99-91-2) → 4-chlorophenacyl acetate (39561-82-5)

Guidance literature:

N,N-dimethyl acetamide; para-chloroacetophenone; With trifluorormethanesulfonic acid; thallium(III) acetate; at 60 ℃; for 0.333333h;

With water; for 0.166667h; Further stages.;

DOI:10.1039/b102192n

Reference yield: 87.0%

1-(4-chlorophenyl)ethenylacetamide (208118-80-3) → 4-chlorophenacyl acetate (39561-82-5)

Guidance literature:

With dihydrogen peroxide; acetic anhydride; In water; at 20 ℃;

DOI:10.1039/c6ob02002j

Reference yield: 86.0%

[bis(acetoxy)iodo]benzene (3240-34-4) + para-chloroacetophenone (99-91-2) → 4-chlorophenacyl acetate (39561-82-5)

Guidance literature:

With acetic acid; scandium tris(trifluoromethanesulfonate); at 50 ℃; for 48h;

DOI:10.1002/ejoc.201800292

upstream raw materials:

1-(4-chlorophenyl)-2-diazoethanone

acetic acid

sodium acetate

4-chlorobenzoylmethyl bromide

Downstream raw materials:

1-(4-chlorophenyl)-2-hydroxyethanone

(S)-1-(4-chlorophenyl)-1,2-ethanediol

(1R)-1-(4-chlorophenyl)-1,2-ethanediol

Refernces

• 1、 Li, Pingfan,Zhang, Zhong. "Sulfur-mediated difunctionalization of internal and terminal alkynes for the synthesis of α-acetoxy ketones". supporting information. . Retrieved 2020/02/13.
• 2、 Chen, Ming,Zhang, Wei,Ren, Zhi-Hui,Gao, Wen-Yun,Wang, Yao-Yu,Guan, Zheng-Hui. "PhI(OAc)2-promoted umpolung acetoxylation of enamides for the synthesis of α-acetoxy ketones". . p. 761 - 768. Retrieved 2017/06/05.