3-Ethyl-5,5-diphenylhydantoin

Base Information

• Chemical Name: 3-Ethyl-5,5-diphenylhydantoin
• CAS No.: 39588-47-1
• Molecular Formula: C17H16N2O2
• Molecular Weight: 280.32100
• Mol file: 39588-47-1.mol

Synonyms:5,5-diphenyl-3-ethylhydantoin;3-ethyl-5,5-diphenyl-imidazolidine-2,4-dione;3-Aethyl-5,5-diphenyl-imidazolidin-2,4-dion;3-Ethyl-5,5-diphenylhydantoin;

Chemical Property of 3-Ethyl-5,5-diphenylhydantoin

Chemical Property:

• PSA: 49.41000
• LogP: 2.76860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethyl-5,5-diphenylhydantoin

There total 11 articles about 3-Ethyl-5,5-diphenylhydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

ethyl bromide (74-96-4) + phenythoin (57-41-0) → 3-ethyl-5,5-diphenylhydantoin (39588-47-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 72h; Ambient temperature;

DOI:10.1002/bscb.19850940611

Reference yield: 60.0%

N-Ethylurea (625-52-5) + benzil (134-81-6) → 3-ethyl-5,5-diphenylhydantoin (39588-47-1)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; microwave irradiation;

DOI:10.1021/jm050977k

Reference yield:

chloroethane (75-00-3) + phenythoin (57-41-0) → 3-ethyl-5,5-diphenylhydantoin (39588-47-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.2298/JSC110314143T

upstream raw materials:

diethyl sulfate

phenythoin

ethyl iodide

N-Ethylurea

Downstream raw materials:

3-Ethyl-1-oxiranylmethyl-5,5-diphenyl-imidazolidine-2,4-dione

1-Allyl-3-ethyl-5,5-diphenyl-imidazolidine-2,4-dione

ethyl 3-ethyl-5,5-diphenyl-1-hydantoin acetate

1-Benzyl-3-ethyl-5,5-diphenyl-imidazolidine-2,4-dione

Refernces

• 1、 Trisovic, Nemanja,Bozic, Bojan,Obradovic, Ana,Stefanovic, Olgica,Markovic, Snezana,Comic, Ljiljana,Bozic, Biljana,Uscumlic, Gordana. "Structure-activity relationships of 3-substituted-5,5-diphenylhydantoins as potential antiproliferative and antimicrobial agents". scheme or table. p. 1597 - 1606. Retrieved 2012/05/07.
• 2、 Muccioli, Giulio G.,Fazio, Nicola,Scriba, Gerhard K. E.,Poppitz, Wolfgang,Cannata, Fabio,Poupaert, Jacques H.,Wouters, Johan,Lambert, Didier M.. "Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates". . p. 417 - 425. Retrieved 2007/10/03.