3,5-Dichloro-2-hydroxybenzoyl chloride

Base Information

• Chemical Name: 3,5-Dichloro-2-hydroxybenzoyl chloride
• CAS No.: 39614-80-7
• Molecular Formula: C7H3Cl3O2
• Molecular Weight: 225.459
• DSSTox Substance ID: DTXSID301282753
• Mol file: 39614-80-7.mol

Synonyms:3,5-dichloro-2-hydroxybenzoyl chloride;39614-80-7;SCHEMBL4891035;NMRFTQSCAAZYSL-UHFFFAOYSA-N;DTXSID301282753;3,5-Dichloro-2-hydroxy-benzoyl Chloride

Chemical Property of 3,5-Dichloro-2-hydroxybenzoyl chloride

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.919862
• Heavy Atom Count: 12
• Complexity: 186

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1C(=O)Cl)O)Cl)Cl

Technology Process of 3,5-Dichloro-2-hydroxybenzoyl chloride

There total 6 articles about 3,5-Dichloro-2-hydroxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

sodium 3,5-chloro-2-hydroxybenzoate (106086-54-8) → 3,5-dichloro-2-hydroxy-benzoyl chloride (39614-80-7)

Guidance literature:

With thionyl chloride; In benzene; at 75 ℃; for 4h;

Reference yield:

3,5-dichlorosalicylic acid (320-72-9) → 3,5-dichloro-2-hydroxy-benzoyl chloride (39614-80-7)

Guidance literature:

With phosphorus pentachloride;

DOI:10.1007/BF02803178

Reference yield:

1,4-benzoxazine (5735-53-5) → 3,5-dichloro-2-hydroxy-benzoyl chloride (39614-80-7)

Guidance literature:

In (3,5-dichloro-2-hydroxyphenyl)-(2,3-dihydrobenzo[1,4]oxazin-4-yl)-methanone;

upstream raw materials:

3,5-dichlorosalicylic acid

sodium 3,5-chloro-2-hydroxybenzoate

phosphorus pentachloride

salicylic acid

Downstream raw materials:

3,5-dichloro-2-hydroxy-benzoic acid-(3,5-dichloro-2-hydroxy-anilide)

3,5-dichloro-N-(4-chlorophenyl)-2-hydroxybenzamide

3,5-dichloro-2-hydroxy-N-benzamide

3,5-dichloro-2-hydroxy-N-[4-(4-hydroxy-phenyl)-thiazol-2-yl]-benzamide

Refernces

• 1、 Krátky, Martin,Vu, Quynh Anh,?těpánková, ?árka,Maruca, Annalisa,Silva, Tiago Barros,Ambro?, Martin,Pflégr, Václav,Rocca, Roberta,Svr?ková, Katarína,Alcaro, Stefano,Borges, Fernanda,Vin?ová, Jarmila. "Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study". . . Retrieved 2021/09/07.
• 2、 Blake, Steven,Thanissery, Rajani,Rivera, Alissa J.,Hixon, Mark S.,Lin, Mingliang,Theriot, Casey M.,Janda, Kim D.. "Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice". . p. 6898 - 6908. Retrieved 2020/07/28.