Pyrrolidine, 2,2-dimethoxy-1-methyl-

Base Information

• Chemical Name: Pyrrolidine, 2,2-dimethoxy-1-methyl-
• CAS No.: 39650-82-3
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• European Community (EC) Number: 832-957-2
• DSSTox Substance ID: DTXSID30454158
• Wikidata: Q82275515
• Mol file: 39650-82-3.mol

Synonyms:2,2-dimethoxy-1-methylpyrrolidine;39650-82-3;Pyrrolidine, 2,2-dimethoxy-1-methyl-;N-methyl-2-pyrrolidone dimethyl acetal;SCHEMBL5915754;DTXSID30454158;IWVFFVBJTCPIIG-UHFFFAOYSA-N;EN300-118986

Chemical Property of Pyrrolidine, 2,2-dimethoxy-1-methyl-

Chemical Property:

• PSA: 21.70000
• LogP: 0.59650
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 145.110278721
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

99% ^*data from raw suppliers

2,2-dimethoxy-1-methyl-Pyrrolidine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC1(OC)OC

Technology Process of Pyrrolidine, 2,2-dimethoxy-1-methyl-

There total 6 articles about Pyrrolidine, 2,2-dimethoxy-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + dimethyl sulfate (77-78-1) → 2,2-dimethoxy-1-methylpyrrolidine (39650-82-3)

Guidance literature:

With sodium; 1.) 90 deg C, 1 h; 2.) MeOH, -10 deg C, 1 h;

DOI:10.1021/ja00268a052

Reference yield: 40.0%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + sodium methylate (124-41-4) + dimethyl sulfate (77-78-1) → 2,2-dimethoxy-1-methylpyrrolidine (39650-82-3)

Guidance literature:

1-methyl-pyrrolidin-2-one; dimethyl sulfate; at 90 ℃; for 1.5h;

sodium methoxide; With methanol; at -10 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.08.030

Reference yield:

methanol (67-56-1) + O-methyl-N-methylpyrrolidonium methylsulfate (117028-40-7) → 2,2-dimethoxy-1-methylpyrrolidine (39650-82-3)

Guidance literature:

With sodium methylate; at 50 ℃;

DOI:10.1016/S0040-4039(00)76669-X

upstream raw materials:

1-methyl-pyrrolidin-2-one

dimethyl sulfate

methanol

O-methyl-N-methylpyrrolidonium methylsulfate

Downstream raw materials:

dimethyl cis-but-2-ene-1,4-dioate

2-(1-methyl-2-pyrrolidinylideneamino)pyrimidine

(3-Methyl-pyridin-2-yl)-[1-methyl-pyrrolidin-(2Z)-ylidene]-amine

Dimethyl succinate

Refernces

• 1、 Paetzel, Michael,Knoll, Alexander,Steinke, Thomas,Loewis, Michael von,Liebscher, Juergen. "Ring Chain Transformations. XII. Synthesis of N-(3-Aminothioacryloyl)lactam Imines and their Transformation to 4-(ω-Amino-alkyl)thiazoles or N-(Thien-2-yl)lactam Imines". . p. 639 - 643. Retrieved 1993.
• 2、 -. "PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF". Paragraph 00179. . Retrieved 2015/11/23.
• 3、 Lu, Jun,Khdour, Omar M.,Armstrong, Jeffrey S.,Hecht, Sidney M.. "Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant". experimental part. p. 7628 - 7638. Retrieved 2011/01/04.