Quinoline, 2-[3-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Quinoline, 2-[3-(trifluoromethyl)phenyl]-
• CAS No.: 396-84-9
• Molecular Formula: C16H10F3N
• Molecular Weight: 273.257
• Mol file: 396-84-9.mol

Synonyms:

Chemical Property of Quinoline, 2-[3-(trifluoromethyl)phenyl]-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoline, 2-[3-(trifluoromethyl)phenyl]-

There total 11 articles about Quinoline, 2-[3-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Aminobenzyl alcohol (5344-90-1) + 3'-(trifluoromethyl)acetophenone (349-76-8) → 2-(3-(trifluoromethyl)phenyl)quinoline (396-84-9)

Guidance literature:

With potassium hydroxide; Grubbs catalyst first generation; In 1,4-dioxane; at 80 ℃; for 1h;

DOI:10.1039/b109245f

Reference yield: 92.0%

2-Chloroquinoline (612-62-4) + (3-(trifluoromethyl)phenyl)magnesium bromide-lithium chloride → 2-(3-(trifluoromethyl)phenyl)quinoline (396-84-9)

Guidance literature:

With ferric(III) bromide; In tetrahydrofuran; tert-butyl methyl ether; at 20 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol302136c

Reference yield: 88.0%

2-bromoquinoline (2005-43-8) + (meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → 2-(3-(trifluoromethyl)phenyl)quinoline (396-84-9)

Guidance literature:

With potassium phosphate monohydrate; (PCy₃)Pd(crotyl)Cl; FI-750-M; In water; at 45 ℃; Inert atmosphere; Micellar solution; Green chemistry;

DOI:10.1002/cctc.201800958

upstream raw materials:

n-butyllithium

3-bromo-1-trifluoromethylbenzene

diethyl ether

3-(2-amino-phenyl)-1-(3-trifluoromethyl-phenyl)-propynone

Downstream raw materials:

(R)-2-(3-trifluoromethylphenyl)-1,2,3,4-tetrahydroquinoline

Refernces

• 1、 Rahul,Nitha,Omanakuttan, Vishnu K.,Babu, Sheba Ann,Sasikumar,Praveen, Vakayil K.,Hopf, Henning,John, Jubi. "Superbase-Mediated Indirect Friedl?nder Reaction: A Transition Metal-Free Oxidative Annulation toward Functionalized Quinolines". . p. 3081 - 3089. Retrieved 2020/05/08.
• 2、 Mahajan, Akhil,Arya, Anju,Chundawat, Tejpal Singh. "Green synthesis of silver nanoparticles using green alga (Chlorella vulgaris) and its application for synthesis of quinolines derivatives". supporting information. p. 1926 - 1937. Retrieved 2019/05/17.