N-(4-methylphenyl)thiophene-2-sulfonamide

Base Information

• Chemical Name: N-(4-methylphenyl)thiophene-2-sulfonamide
• CAS No.: 39810-48-5
• Molecular Formula: C₁₁H₁₁NO₂S₂
• Molecular Weight: 253.346
• DSSTox Substance ID: DTXSID30353319
• Wikidata: Q82130822
• Mol file: 39810-48-5.mol

Synonyms:N-(4-methylphenyl)thiophene-2-sulfonamide;39810-48-5;SCHEMBL10192087;DTXSID30353319;STK392958;AKOS001614795;CCG-108434;N-(4-methylphenyl)-2-thiophenesulfonamide;EU-0007427;AQ-390/12072034;SR-01000456196;SR-01000456196-1;Z45633620

Chemical Property of N-(4-methylphenyl)thiophene-2-sulfonamide

Chemical Property:

• PSA: 82.79000
• LogP: 4.01110
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 253.02312094
• Heavy Atom Count: 16
• Complexity: 315

Purity/Quality:

N-(4-METHYLPHENYL)THIOPHENE-2-SULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NS(=O)(=O)C2=CC=CS2

Technology Process of N-(4-methylphenyl)thiophene-2-sulfonamide

There total 2 articles about N-(4-methylphenyl)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

thiophene-2-sulfonyl chloride (16629-19-9) + p-toluidine (106-49-0,12221-03-3) → 2-Thienylsulfonyl-p-toluidid (39810-48-5)

Guidance literature:

With sodium acetate; In ethanol; for 24h;

Reference yield:

→ 2-Thienylsulfonyl-p-toluidid (39810-48-5)

Guidance literature:

2-Thiophensulfonylchlorid, p-Toluidin;

DOI:10.1021/jo00954a010

Reference yield: 45.0%

2-Thienylsulfonyl-p-toluidid (39810-48-5) + chlorothio-trichloro-methane (594-42-3) → N-trichloromethylsulfenyl N-p-tolylthiophene-2-sulfonamide

Guidance literature:

With sodium hydroxide; In diethyl ether; for 3h; Heating;

upstream raw materials:

thiophene-2-sulfonyl chloride

p-toluidine

Refernces

• 1、 Cremlyn, Richard J.,Goulding, Kenneth H.,Swinbourne, Frederick J.,Yung, Kin-Man. "THE REACTIONS OF SOME THIOPHENE SULFONYL DERIVATVES". . p. 111 - 120. Retrieved 2007/10/02.