Estetrol

Base Information Edit

Chemical Name:Estetrol
CAS No.:15183-37-6
Molecular Formula:C18H24O4
Molecular Weight:304.386
Hs Code.:
European Community (EC) Number:840-340-4,844-239-6
UNII:ENB39R14VF
DSSTox Substance ID:DTXSID50164888
Nikkaji Number:J15.350H
Wikipedia:Estetrol
Wikidata:Q5401078
NCI Thesaurus Code:C68928,C169963
RXCUI:2539031
Pharos Ligand ID:JDQUMBANBJUN
Metabolomics Workbench ID:153262
ChEMBL ID:CHEMBL1230314
Mol file:15183-37-6.mol

Synonyms:15 alpha Hydroxy Estriol;15 alpha Hydroxyestriol;15 alpha-Hydroxyestriol;15-alpha-Hydroxy-Estriol;Estetrol

Suppliers and Price of Estetrol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Estetrol
5mg
$ 205.00

Sigma-Aldrich
Estetrol ≥98% (HPLC)
5mg
$ 183.00

Sigma-Aldrich
Estetrol ≥98% (HPLC)
25mg
$ 729.00

ChemScene
Estetrol 95.46%
1mg
$ 160.00

Cayman Chemical
Estetrol ≥95%
1mg
$ 63.00

Cayman Chemical
Estetrol ≥95%
500μg
$ 35.00

Cayman Chemical
Estetrol ≥95%
5mg
$ 158.00

Biosynth Carbosynth
Estetrol
1 mg
$ 120.00

Biosynth Carbosynth
Estetrol
10 mg
$ 575.00

Biosynth Carbosynth
Estetrol
5 mg
$ 325.00

Total 41 raw suppliers

Chemical Property of Estetrol Edit

Chemical Property:

Melting Point:233-236°C
Refractive Index:1.65
Boiling Point:491.9 °C at 760 mmHg
PKA:10.22±0.70(Predicted)
Flash Point:231.7 °C
PSA：80.92000
Density:1.343 g/cm³
LogP:1.55080
Storage Temp.:-20?C Freezer
Solubility.:DMSO: soluble20mg/mL, clear
XLogP3:1.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:304.16745924
Heavy Atom Count:22
Complexity:441

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Estetrol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC3C(C1C(C(C2O)O)O)CCC4=C3C=CC(=C4)O
Isomeric SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O
Recent ClinicalTrials:Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women
Recent EU Clinical Trials:A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 STUDY TO ASSESS THE INFLUENCE OF ESTETROL (E4) ON SKIN PARAMETERS IN POSTMENOPAUSAL WOMEN (PILOT STUDY)
Recent NIPH Clinical Trials:Phase II study to evaluate pharmacodynamics, pharmacokinetics and safety after cyclic dose or continuous dose of FSN-013 for 3 cycles in Japanese healthy adult female subjects
Uses Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium). In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth. A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.

Technology Process of Estetrol

There total 27 articles about Estetrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.22%