1-p-Tolylcyclopropanol

Base Information

• Chemical Name: 1-p-Tolylcyclopropanol
• CAS No.: 40122-37-0
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• Mol file: 40122-37-0.mol

Synonyms:1-(p-tolyl)cyclopropanol;1-P-TOLYLCYCLOPROPANOL;1-p-Tolyl-cyclopropanol;1-p-Tolyl-1-cyclopropanol;1-(p-Methylphenyl)cyclopropanol;1-(p-Methylphenyl)-1-cyclopropanol;1-p-Methyl-phenyl-cyclopropanol-(1);

Chemical Property of 1-p-Tolylcyclopropanol

Chemical Property:

• Boiling Point: 70 - 80 °C (0.4 mmHg)
• PSA: 20.23000
• LogP: 1.97640

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-p-Tolylcyclopropanol

There total 12 articles about 1-p-Tolylcyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

4-methyl-benzoic acid methyl ester (99-75-2) + ethylmagnesium bromide (925-90-6) → 1-(p-tolyl)cyclopropan-1-ol (40122-37-0)

Guidance literature:

With titanium(IV)isopropoxide; In tetrahydrofuran; at 0 - 20 ℃; for 24.5h; Inert atmosphere;

Reference yield: 68.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-p-methylphenyl-1-trimethylsiloxyethene (54731-27-0) → 1-(p-tolyl)cyclopropan-1-ol (40122-37-0)

Guidance literature:

With iodine; triethylaluminum; In dichloromethane; at 0 - 23 ℃; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1007/s11172-019-2638-5

Reference yield: 55.0%

4-methyl-benzoic acid methyl ester (99-75-2) + ethylmagnesium chloride (2386-64-3) → 1-(p-tolyl)cyclopropan-1-ol (40122-37-0)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1039/c5ob00808e

upstream raw materials:

Trimethyl-(1-p-tolyl-cyclopropoxy)-silane

1,3-Dichloroacetone

para-methylphenylmagnesium bromide

Ethyl 3-bromopropionate

Downstream raw materials:

1-(4'-methylphenyl)-4,4,4-trifluoro-1-butanone

Refernces

• 1、 Liu, Jidan,Yang, Zhenke,Jiang, Jinyuan,Zeng, Qiaohai,Zheng, Liyao,Liu, Zhao-Qing. "Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones". supporting information. p. 5927 - 5931. Retrieved 2021/07/31.
• 2、 Liu, Jidan,Xu, Erjie,Jiang, Jinyuan,Huang, Zeng,Zheng, Liyao,Liu, Zhao-Qing. "Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: Synthesis of: N -arylpyrazoles". supporting information. p. 2202 - 2205. Retrieved 2020/02/26.