3-(Chloromethoxy)-1-propyne

Base Information

• Chemical Name: 3-(Chloromethoxy)-1-propyne
• CAS No.: 40308-66-5
• Molecular Formula: C4H5ClO
• Molecular Weight: 104.536
• Mol file: 40308-66-5.mol

Synonyms:(propargyloxy)methyl chloride;chloromethyl 2-propyn-1-yl ether;chloromethyl propargyl ether;1-Propyne,3-(chloromethoxy);chloromethyl 2-propynyl ether;propargyloxy-chloromethane;2-propynyloxymethyl chloride;

Chemical Property of 3-(Chloromethoxy)-1-propyne

Chemical Property:

• PSA: 9.23000
• LogP: 0.83250

Purity/Quality:

99% ^*data from raw suppliers

1-Propyne,3-(chloromethoxy)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Chloromethoxy)-1-propyne

There total 5 articles about 3-(Chloromethoxy)-1-propyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

propargyl alcohol (107-19-7) → 3-chloromethoxy-propyne (40308-66-5)

Guidance literature:

With paraformaldehyde;

Reference yield: 60.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + propargyl alcohol (107-19-7) → 3-chloromethoxy-propyne (40308-66-5) + bis<(propargyloxy)methyl> ether (139758-75-1)

Guidance literature:

With hydrogenchloride; In water; at -25 - -20 ℃; for 0.75h;

DOI:10.1021/jm00086a012

Reference yield: 49.6%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + propargyl alcohol (107-19-7) → 3-chloromethoxy-propyne (40308-66-5)

Guidance literature:

With hydrogenchloride; In chloroform; at 0 - 5 ℃; for 2h;

DOI:10.1007/BF00531547

upstream raw materials:

1,3,5-Trioxan

propargyl alcohol

formaldehyd

Downstream raw materials:

C₁₂H₁₀O₅

2-[(prop-2-yn-1-yl)oxy]-1-phenylethan-1-ol

Refernces

• 1、 Ozerov, A. A.,Brel', A. K.. "NEW ACETENYL ACYCLIC NUCLEOSIDES. SYNTHESIS OF 1-(PROPARGYLOXYMETHYL) DERIVATIVES OF URACIL". . p. 684 - 686. Retrieved 1993.
• 2、 Hasan,Srivastava. "Synthesis and biological studies of unsaturated acyclonucleoside analogues of S-adenosyl-L-homocysteine hydrolase inhibitors". . p. 1435 - 1439. Retrieved 2007/10/02.