2-oxopyrrolidine-1-carbaldehyde

Base Information

• Chemical Name: 2-oxopyrrolidine-1-carbaldehyde
• CAS No.: 40321-44-6
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.116
• Mol file: 40321-44-6.mol

Synonyms:1-Formyl-2-pyrrolidone;1-Pyrrolidinecarboxaldehyde,2-oxo;N-formyl pyrrolidin-2-one;N-methylpyrrolidone;1-formyl-pyrrolidin-2-one;2-oxo-pyrrolidine-1-carbaldehyde;N-Formyl-pyrrolidon-(2);N-formyl-2-pyrrolidinone;

Chemical Property of 2-oxopyrrolidine-1-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.566mmHg at 25°C
• Boiling Point: 189.6oC at 760 mmHg
• Flash Point: 79.6oC
• PSA: 37.38000
• Density: 1.365g/cm3
• LogP: 0.33900

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Oxopyrrolidine-1-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-oxopyrrolidine-1-carbaldehyde

There total 9 articles about 2-oxopyrrolidine-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-pyrrolidinon (616-45-5) + N,N-Diformylacetamide (26944-31-0) → 2-oxo-pyrrolidine-1-carbaldehyde (40321-44-6)

Guidance literature:

In benzene; Heating;

DOI:10.1055/s-1982-29771

Reference yield: 23.0%

1-(1-hydroxy-2-oxo-2-phenylethyl)pyrrolidin-2-one (132150-49-3) → 2-oxo-pyrrolidine-1-carbaldehyde (40321-44-6) + erithro-5-<α-hydroxybenzyl>pyrrolidin-2-one (111492-57-0,111492-58-1)

Guidance literature:

In acetonitrile; for 20h; Irradiation;

DOI:10.1016/S0040-4020(01)90072-9

Reference yield:

1-Methylpyrrolidine (120-94-5) → 2-pyrrolidinon (616-45-5) + 1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 2-oxo-pyrrolidine-1-carbaldehyde (40321-44-6) + N-methylpyrrolidine N-oxide (7529-17-1)

Guidance literature:

With oxygen; In water; at 55 ℃; Mechanism; relative rates of tertiary aliphatic amines oxidation, var. initiators, var. inhibitors, irradiation, var. solvents, var. temperatures;

upstream raw materials:

1-Methylpyrrolidine

2-pyrrolidinon

N,N-Diformylacetamide

1-(1-hydroxy-2-oxo-2-phenylethyl)pyrrolidin-2-one

Downstream raw materials:

2-pyrrolidinon

Refernces

• 1、 Molina De La Torre, Jesus A.,Espinet, Pablo,Albeniz, Ana C.. "Solvent-induced reduction of palladium-aryls, a potential interference in pd catalysis". . p. 5428 - 5434. Retrieved 2013/11/06.
• 2、 Villa, Mathew V. J.,Targett, Sarah M.,Barnes, John C.,Whittingham, William G.,Marquez, Rodolfo. "An efficient approach to the stereocontrolled synthesis of enamides". . p. 1631 - 1633. Retrieved 2008/02/02.