benzhydrylsulfonylbenzene

Base Information

• Chemical Name: benzhydrylsulfonylbenzene
• CAS No.: 5433-76-1
• Molecular Formula: C19H16O2S
• Molecular Weight: 308.401
• Mol file: 5433-76-1.mol

Synonyms:

Chemical Property of benzhydrylsulfonylbenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzhydrylsulfonylbenzene

There total 22 articles about benzhydrylsulfonylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,1-Diphenylmethanol (91-01-0) + sodium benzenesulfonate (873-55-2) → diphenylmethyl phenyl sulfone (5433-76-1)

Guidance literature:

With iron(III) chloride; chloro-trimethyl-silane; In dichloromethane; at 50 ℃; for 5h;

DOI:10.1002/adsc.200900905

Reference yield: 82.0%

bromobenzene (108-86-1,52753-63-6) + Benzyl phenyl sulfone (3112-88-7) → diphenylmethyl phenyl sulfone (5433-76-1) + phenyl-trityl sulfone

Guidance literature:

Benzyl phenyl sulfone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at -20 - 20 ℃; for 1h; Inert atmosphere;

bromobenzene; With palladium diacetate; XPhos; In tetrahydrofuran; at 65 ℃; Degassed under vacuum; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.12.035

Reference yield: 82.0%

iodobenzene (591-50-4) + Benzyl phenyl sulfone (3112-88-7) → diphenylmethyl phenyl sulfone (5433-76-1)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 80 ℃; for 12h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere;

DOI:10.1002/anie.201307019

upstream raw materials:

1,1-Diphenylmethanol

Benzenesulfinic acid

phenyl 2,2-diphenylethenyl sulfone

hydrogenchloride

Downstream raw materials:

<4-(trimethylsilyl)phenyl>diphenylmethane

1-(4-diphenylmethyl)phenylethanone

1-(diphenylmethyl)-2-methylbenzene

diphenyl(3-thienyl)methane

Refernces

• 1、 Nambo, Masakazu,Ariki, Zachary T.,Canseco-Gonzalez, Daniel,Beattie, D. Dawson,Crudden, Cathleen M.. "Arylative Desulfonation of Diarylmethyl Phenyl Sulfone with Arenes Catalyzed by Scandium Triflate". supporting information. p. 2339 - 2342. Retrieved 2016/06/09.
• 2、 Zhou, Gang,Ting, Pauline C.,Aslanian, Robert G.. "Palladium-catalyzed Negishi α-arylation of alkylsulfones". experimental part. p. 939 - 941. Retrieved 2010/05/18.