2,2,2-Trifluoro-4'-nitroacetanilide

Base Information

• Chemical Name: 2,2,2-Trifluoro-4'-nitroacetanilide
• CAS No.: 404-27-3
• Molecular Formula: C8H5F3N2O3
• Molecular Weight: 234.135
• Hs Code.: 2924299090
• Mol file: 404-27-3.mol

Synonyms:2,2,2-trifluoro-N-(4-nitrophenyl)acetamide;

Chemical Property of 2,2,2-Trifluoro-4'-nitroacetanilide

Chemical Property:

• Melting Point: 149-150oC
• PSA: 74.92000
• LogP: 2.69180

Purity/Quality:

98%min ^*data from raw suppliers

N-(p-Nitrophenyl)-2,2,2-trifluoroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(p-Nitrophenyl)-2,2,2-trifluoroacetamide (cas# 404-27-3) is a compound useful in organic synthesis.

Technology Process of 2,2,2-Trifluoro-4'-nitroacetanilide

There total 23 articles about 2,2,2-Trifluoro-4'-nitroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trifluoroacetic acid (76-05-1) + S,S-di-n-butyl-N-(4-nitrophenyl)imino-λ4-sulfane → butyl sulfoxide (2168-93-6) + 2,2,2-trifluoro-N-(4-nitrophenyl)acetamide (404-27-3) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

at 72 ℃; for 72h;

DOI:10.1039/a803039a

Reference yield: 97.0%

4-nitro-aniline (100-01-6,104810-17-5) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(4-nitrophenyl)acetamide (404-27-3)

Guidance literature:

In pyridine; at 0 - 20 ℃; for 18h;

Reference yield: 97.0%

4-nitro-aniline (100-01-6,104810-17-5) + trifluoroacetic acid (76-05-1) → 2,2,2-trifluoro-N-(4-nitrophenyl)acetamide (404-27-3)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.2174/157017811797249317

upstream raw materials:

4-nitro-aniline

trifluoroacetic anhydride

2-(trifluoroacetyloxy)pyridine

2,2,2-trifluoro-N-phenylacetamide

Downstream raw materials:

(2-amino-5-nitro-phenyl)-pyridin-2-yl-methanone

2,2,2-trifluoroethanol

4-nitro-aniline

Hexadecanoic acid (4-diethylamino-1-methyl-butyl)-[4-(3-{4-[(4-diethylamino-1-methyl-butyl)-hexadecanoyl-amino]-phenyl}-ureido)-phenyl]-amide

Refernces

• 1、 Yang, Pengfei,Moloney, Mark G.. "Surface modification of polymers with bis(arylcarbene)s from bis(aryldiazomethane)s: preparation, dyeing and characterization". . p. 111276 - 111290. Retrieved 2016.
• 2、 Heuckendorff, Mads,Jensen, Henrik H.. "Removal of some common glycosylation by-products during reaction work-up". . p. 50 - 56. Retrieved 2017/01/22.