2-(chloromethoxy)ethyl Acetate

Base Information

• Chemical Name: 2-(chloromethoxy)ethyl Acetate
• CAS No.: 40510-88-1
• Molecular Formula: C5H9ClO3
• Molecular Weight: 152.578
• European Community (EC) Number: 881-437-1
• DSSTox Substance ID: DTXSID90434436
• Mol file: 40510-88-1.mol

Synonyms:2-(chloromethoxy)ethyl Acetate;40510-88-1;Acetic acid 2-chloromethoxy-ethyl ester;Acetoxyethyloxymethylchloride;2-(chloromethoxy)ethylAcetate;SCHEMBL215693;2-Chloromethoxy ethanol acetate;2-acetoxyethyl chloromethyl ether;DTXSID90434436;PAHCSXMDRKCMGY-UHFFFAOYSA-N;1-acetoxy-2-(chloromethoxy)ethane;MFCD00623620;AKOS006274495;FT-0712605;F74792

Chemical Property of 2-(chloromethoxy)ethyl Acetate

Chemical Property:

• Refractive Index: 1.4373 (589.3 nm 20℃)
• Boiling Point: 78-81℃ (6 Torr)
• PSA: 35.53000
• Density: 1.1895 g/cm3(Temp: 200 °C)
• LogP: 0.76240
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 152.0240218
• Heavy Atom Count: 9
• Complexity: 84.3

Purity/Quality:

≥99.0% ^*data from raw suppliers

2-(Chloromethoxy)ethyl acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCCOCCl

Technology Process of 2-(chloromethoxy)ethyl Acetate

There total 3 articles about 2-(chloromethoxy)ethyl Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-DIOXOLANE (646-06-0) + acetyl chloride (75-36-5) → 1-acetoxy-2-chloromethoxyethane (40510-88-1)

Guidance literature:

With zinc(II) chloride; In diethyl ether; at 19 - 27 ℃; for 5.33333h;

Reference yield:

1,3-DIOXOLANE (646-06-0) + acetyl chloride (75-36-5) + zinc(II) chloride (7646-85-7,24359-56-6) → 1-acetoxy-2-chloromethoxyethane (40510-88-1)

Guidance literature:

Reference yield:

→ 1-acetoxy-2-chloromethoxyethane (40510-88-1)

Guidance literature:

upstream raw materials:

1,3-DIOXOLANE

acetyl chloride

zinc(II) chloride

Downstream raw materials:

Essigsaeure-<2-(5-chlor-pent-3-enyloxy)-ethylester>

2-hydroxyethyl acetate

2-(cyclohex-2-enyloxymethoxy)ethanol

2-(cyclohex-3-enyloxymethoxy)ethanol

Refernces

• 1、 Chen,Flavin,Filler,Xu. "Introduction of α-fluorophosphonomethyl ether functionality and its application to the synthesis of fluorinated acyclic phosphonate nucleosides". . p. 8975 - 8978. Retrieved 1996.
• 2、 Puig-De-La-Bellacasa, Raimon,Gimenez, Laura,Pettersson, Sofia,Pascual, Rosalia,Gonzalo, Encarna,Este, Jose A.,Clotet, Bonaventura,Borrell, Jose I.,Teixido, Jordi. "Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors". scheme or table. p. 159 - 174. Retrieved 2012/09/05.
• 3、 Schwanke, Anja,Murruzzu, Caterina,Zdrazil, Barbara,Zuhse, Ralf,Natek, Maja,H?ltje, Monika,Korting, Hans Christian,Reissig, Hans-Ulrich,H?ltje, Hans-Dieter,Sch?fer-Korting, Monika. "Antitumor effects of guanosine-analog phosphonates identified by molecular modelling". scheme or table. p. 9 - 18. Retrieved 2011/12/15.