Benzenemethanamine, N-phenyl-4-(trifluoromethyl)-

Base Information

• Chemical Name: Benzenemethanamine, N-phenyl-4-(trifluoromethyl)-
• CAS No.: 405-80-1
• Molecular Formula: C14H12F3N
• Molecular Weight: 251.251
• Mol file: 405-80-1.mol

Synonyms:

Chemical Property of Benzenemethanamine, N-phenyl-4-(trifluoromethyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, N-phenyl-4-(trifluoromethyl)-

There total 24 articles about Benzenemethanamine, N-phenyl-4-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + aniline (62-53-3) → N-phenyl-4-(trifluoromethyl)benzenemethanamine (405-80-1)

Guidance literature:

With (2,6-dichlorophenyl)bis(2,3,5,6-tetrafluorophenyl)borane; hydrogen; In tetrahydrofuran; at 100 ℃; for 6h; under 15201 Torr; Sealed tube; Molecular sieve; Autoclave; Green chemistry;

DOI:10.1021/jacs.8b03626

Reference yield: 99.0%

N-(4-(trifluoromethyl)benzylidene)aniline (79128-83-9) → N-phenyl-4-(trifluoromethyl)benzenemethanamine (405-80-1)

Guidance literature:

With sodium hydride; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1039/d0nj01423k

Reference yield: 93.0%

4-(trifluoromethyl)benzylic alcohol (349-95-1) + aniline (62-53-3) → N-phenyl-4-(trifluoromethyl)benzenemethanamine (405-80-1)

Guidance literature:

With C₃₆H₃₅IrN₂P⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); potassium tert-butylate; at 50 ℃; for 24h; Temperature; Time; Solvent; Inert atmosphere;

DOI:10.1039/c3cc42669f

upstream raw materials:

N-(4-(trifluoromethyl)benzylidene)aniline

phenyl 4-(trifluoromethyl)phenyl ketone oxime

4-Trifluoromethylbenzaldehyde

aniline

Downstream raw materials:

N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)aniline

Refernces

• 1、 Bazkiaei, Adineh Rezaei,Wiseman, Michael,Findlater, Michael. "Iron-catalysed hydroboration of non-activated imines and nitriles: Kinetic and mechanistic studies". . p. 15284 - 15289. Retrieved 2021/05/19.
• 2、 Wu, Di,Bu, Qingqing,Guo, Cheng,Dai, Bin,Liu, Ning. "Cooperative catalysis of molybdenum with organocatalysts for distribution of products between amines and imines". . . Retrieved 2021/02/02.