Benzyl 3-(tert-Butoxycarbonylamino)piperidine-1-carboxylate

Base Information

• Chemical Name: Benzyl 3-(tert-Butoxycarbonylamino)piperidine-1-carboxylate
• CAS No.: 406213-47-6
• Molecular Formula: C18H26N2O4
• Molecular Weight: 334.415
• Hs Code.: 2933399090
• Mol file: 406213-47-6.mol

Synonyms:benzyl 3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate;

Chemical Property of Benzyl 3-(tert-Butoxycarbonylamino)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 471.9±44.0 °C(Predicted)
• PKA: 12.25±0.20(Predicted)
• PSA: 67.87000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 3.64110

Purity/Quality:

98%min ^*data from raw suppliers

Benzyl 3-(tert-butoxycarbonylamino)-piperidine-1-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyl 3-(tert-Butoxycarbonylamino)piperidine-1-carboxylate

There total 4 articles about Benzyl 3-(tert-Butoxycarbonylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + Ethyl nipecotate (71962-74-8) → 3-t-butoxycarbonylaminopiperidin-1-carboxylic acid benzyl ester (406213-47-6)

Guidance literature:

benzyl chloroformate; Ethyl nipecotate; With hydrogenchloride; sodium hydroxide; diphenyl phosphoryl azide; triethylamine; In ethanol; water; ethyl acetate; toluene; at 0 - 20 ℃;

With diphenyl phosphoryl azide; triethylamine; In tert-butyl alcohol; at 20 - 100 ℃; for 21.5h;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + Ethyl nipecotate (71962-74-8) + tert-butyl alcohol (75-65-0) → 3-t-butoxycarbonylaminopiperidin-1-carboxylic acid benzyl ester (406213-47-6)

Guidance literature:

benzyl chloroformate; Ethyl nipecotate; With triethylamine; In ethyl acetate; toluene; at 0 ℃; for 0.5h;

With sodium hydroxide; water; In ethanol; at 20 ℃;

tert-butyl alcohol; With diphenylphosphoranyl azide; triethylamine; at 20 - 100 ℃; for 21.5h;

Reference yield:

3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate (310454-53-6) + tert-butyl alcohol (75-65-0) → 3-t-butoxycarbonylaminopiperidin-1-carboxylic acid benzyl ester (406213-47-6)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; at 20 - 100 ℃; for 21.5h;

upstream raw materials:

benzyl chloroformate

Ethyl nipecotate

3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate

tert-butyl alcohol

Downstream raw materials:

(RS)-benzyl 3-aminopiperidine-1-carboxylate

3-<(t-butyloxycarbonyl)methylamino>-piperidine

t-butyl piperidin-3-ylcarbamate

Refernces

• 1、 -. "1,3-DIHYDROIMIDAZOLE FUSED-RING COMPOUND". Page/Page column 41. . Retrieved 2008/06/13.
• 2、 -. "Condensed imidazole derivatives". . . Retrieved 2008/06/13.