2-(PHENYLHYDRAZONO)MALONIC ACID

Base Information

• Chemical Name: 2-(PHENYLHYDRAZONO)MALONIC ACID
• CAS No.: 40885-82-3
• Molecular Formula: C9H8N2O4
• Molecular Weight: 208.174
• Hs Code.: 2928000090
• Mol file: 40885-82-3.mol

Synonyms:Phenylhydrazono-malonsaeure;phenylhydrazono-malonic acid;Mesoxalsaeure-phenylhydrazon;Ketomalonic acid phenylhydrazone;mesoxalic acid phenylhydrazone;

Chemical Property of 2-(PHENYLHYDRAZONO)MALONIC ACID

Chemical Property:

• Vapor Pressure: 1.71E-08mmHg at 25°C
• Boiling Point: 439.3oC at 760 mmHg
• Flash Point: 219.5oC
• PSA: 98.99000
• Density: 1.41g/cm3
• LogP: 0.69670
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Phenylhydrazono)malonicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(PHENYLHYDRAZONO)MALONIC ACID

There total 15 articles about 2-(PHENYLHYDRAZONO)MALONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dihydroxymalonic acid (560-27-0) + phenylhydrazine (100-63-0) → 2-(phenylhydrazono)malonic acid (40885-82-3)

Guidance literature:

In ethanol; water; Ambient temperature;

DOI:10.1021/jm950626d

Reference yield: 82.0%

phenylhydrazine (100-63-0) + disodium oxomalonate → 2-(phenylhydrazono)malonic acid (40885-82-3)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 1.5h;

Reference yield: 81.0%

diethyl 2-(phenylhydrazono)malonate (6134-59-4) → 2-(phenylhydrazono)malonic acid (40885-82-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.5h; Heating;

DOI:10.1021/jm070387h

upstream raw materials:

2-(Phenylhydrazono)malonsaeure-dimethylester

acetonedicarboxylic acid

phenylhydrazine

mesoxalate de methyle

Downstream raw materials:

2-(phenylhydrazono)-propanedioyl dichloride

(Z)-3-(2-phenylhydrazono)-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

(E)-3-(2-phenylhydrazono)-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

methyl 4-hydroxylcinnoline-3-carboxylate

Refernces

• 1、 Stern, Eric,Muccioli, Giulio G.,Bosier, Barbara,Hamtiaux, Laurie,Millet, Régis,Poupaert, Jacques H.,Hénichart, Jean-Pierre,Depreux, Patrick,Goossens, Jean-Fran?ois,Lambert, Didier M.. "Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: Consequences in receptor affinity and functionality". . p. 5471 - 5484. Retrieved 2008/03/17.
• 2、 Sereni, Laura,Tató, Marco,Sola, Francesco,Brill, Wolfgang K.-D.. "Solid phase synthesis of 6-acylamino-1-alkyl/aryl-4-oxo-1,4- dihydrocinnoline-3-carboxamides". . p. 8561 - 8577. Retrieved 2007/10/03.